Cargando…

Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common cause of dementia in elderly people; currently, there is no efficient treatment. Considering the increase in life expectancy worldwide AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. A great amount of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vrabec, Rudolf, Blunden, Gerald, Cahlíková, Lucie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003045/ https://www.ncbi.nlm.nih.gov/pubmed/36901826 http://dx.doi.org/10.3390/ijms24054399

Ejemplares similares

Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease
por: Cahlíková, Lucie, et al.
Publicado: (2021)

Chemical and Biological Aspects of Montanine-Type Alkaloids Isolated from Plants of the Amaryllidaceae Family
por: Koutová, Darja, et al.
Publicado: (2020)

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease
por: Kohelová, Eliška, et al.
Publicado: (2019)

Amaryllidaceae Alkaloids from Clivia miniata (Lindl.) Bosse (Amaryllidaceae): Isolation, Structural Elucidation, and Biological Activity
por: Šafratová, Marcela, et al.
Publicado: (2022)

Ajmalicine and Reserpine: Indole Alkaloids as Multi-Target Directed Ligands Towards Factors Implicated in Alzheimer’s Disease
por: Kashyap, Priya, et al.
Publicado: (2020)

Derivatives of Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Hepatic Stage of Plasmodium berghei Infection In Vitro
por: Breiterová, Kateřina Hradiská, et al.
Publicado: (2023)

Alkaloids of Dicranostigma franchetianum (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents
por: Wijaya, Viriyanata, et al.
Publicado: (2022)

Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae)
por: Cahlíková, Lucie, et al.
Publicado: (2020)

The Genus Nerine Herb. (Amaryllidaceae): Ethnobotany, Phytochemistry, and Biological Activity
por: Cahlíková, Lucie, et al.
Publicado: (2019)

Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities
por: Ritomská, Aneta, et al.
Publicado: (2023)

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae)
por: Siatka, Tomáš, et al.
Publicado: (2017)

Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases
por: Kong, Yew Rong, et al.
Publicado: (2021)

Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?
por: Parvin, Mst Shamima, et al.
Publicado: (2022)

Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
por: Hulcová, Daniela, et al.
Publicado: (2018)

Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources
por: Tamfu, Alfred Ngenge, et al.
Publicado: (2021)

Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase
por: Al Mamun, Abdullah, et al.
Publicado: (2020)

Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids
por: Maříková, Jana, et al.
Publicado: (2021)

Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer’s Disease
por: Wang, Shanshan, et al.
Publicado: (2022)

Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells
por: Koutova, Darja, et al.
Publicado: (2020)

Semisynthetic Derivatives of Selected Amaryllidaceae Alkaloids as a New Class of Antimycobacterial Agents
por: Maafi, Negar, et al.
Publicado: (2021)

Natural Bioactive Compounds Targeting Epigenetic Pathways in Cancer: A Review on Alkaloids, Terpenoids, Quinones, and Isothiocyanates
por: El Omari, Nasreddine, et al.
Publicado: (2021)

Amaryllidaceae Alkaloids of Different Structural Types from Narcissus L. cv. Professor Einstein and Their Cytotoxic Activity
por: Breiterová, Kateřina, et al.
Publicado: (2020)

Proposing novel natural compounds against Alzheimer’s disease targeting acetylcholinesterase
por: Girgin, Münteha, et al.
Publicado: (2023)

Pancracine, a Montanine-Type Amaryllidaceae Alkaloid, Inhibits Proliferation of A549 Lung Adenocarcinoma Cells and Induces Apoptotic Cell Death in MOLT-4 Leukemic Cells
por: Koutová, Darja, et al.
Publicado: (2021)

Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity
por: Ghanem, Simona S., et al.
Publicado: (2021)

Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
por: Mamun, Abdullah Al, et al.
Publicado: (2021)

Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease
por: Capurro, Valeria, et al.
Publicado: (2013)

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease
por: Piemontese, Luca, et al.
Publicado: (2018)

Molecular docking analysis of alkaloid compounds with beta-catenin towards the treatment of colon cancer
por: Ponnulakshmi, Rajagopal, et al.
Publicado: (2020)

Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer’s agents
por: Castillo-Ordoñez, Willian Orlando, et al.
Publicado: (2023)

Antiproliferative activities of alkaloid-like compounds
por: Xu, XiXi, et al.
Publicado: (2017)

The Natural Alkaloid Palmatine Selectively Induces Mitophagy and Restores Mitochondrial Function in an Alzheimer’s Disease Mouse Model
por: Lee, Da-Ye, et al.
Publicado: (2023)

Hybrid approach to sieve out natural compounds against dual targets in Alzheimer’s Disease
por: Das, Sucharita, et al.
Publicado: (2019)

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease
por: Vicente-Zurdo, David, et al.
Publicado: (2022)

Selective cytotoxicity of Pancratistatin-related natural Amaryllidaceae alkaloids: evaluation of the activity of two new compounds
por: Griffin, Carly, et al.
Publicado: (2007)

Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment
por: Luo, Yanming, et al.
Publicado: (2021)

Chemistry and bioactivities of natural steroidal alkaloids
por: Xiang, Mei-Ling, et al.
Publicado: (2022)

Hepatotoxicity of Pyrrolizidine Alkaloid Compound Intermedine: Comparison with Other Pyrrolizidine Alkaloids and Its Toxicological Mechanism
por: Wang, Ziqi, et al.
Publicado: (2021)

Molecular Human Targets of Bioactive Alkaloid-Type Compounds from Tabernaemontana cymose Jacq.
por: Oliveros-Díaz, Andrés, et al.
Publicado: (2021)

Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro
por: Troost, Berit, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1qai9vqihqr2pssbuogqphblgh