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Role of Dopamine in the Heart in Health and Disease

Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects were strong, very modest, or absent, or even ne...

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Autores principales: Neumann, Joachim, Hofmann, Britt, Dhein, Stefan, Gergs, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003060/
https://www.ncbi.nlm.nih.gov/pubmed/36902474
http://dx.doi.org/10.3390/ijms24055042
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author Neumann, Joachim
Hofmann, Britt
Dhein, Stefan
Gergs, Ulrich
author_facet Neumann, Joachim
Hofmann, Britt
Dhein, Stefan
Gergs, Ulrich
author_sort Neumann, Joachim
collection PubMed
description Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects were strong, very modest, or absent, or even negative inotropic effects occurred. We can discern five dopamine receptors. In addition, the signal transduction by dopamine receptors and the regulation of the expression of cardiac dopamine receptors will be of interest to us, because this might be a tempting area of drug development. Dopamine acts in a species-dependent fashion on these cardiac dopamine receptors, but also on cardiac adrenergic receptors. We will discuss the utility of drugs that are currently available as tools to understand cardiac dopamine receptors. The molecule dopamine itself is present in the mammalian heart. Therefore, cardiac dopamine might act as an autocrine or paracrine compound in the mammalian heart. Dopamine itself might cause cardiac diseases. Moreover, the cardiac function of dopamine and the expression of dopamine receptors in the heart can be altered in diseases such as sepsis. Various drugs for cardiac and non-cardiac diseases are currently in the clinic that are, at least in part, agonists or antagonists at dopamine receptors. We define the research needs in order to understand dopamine receptors in the heart better. All in all, an update on the role of dopamine receptors in the human heart appears to be clinically relevant, and is thus presented here.
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spelling pubmed-100030602023-03-11 Role of Dopamine in the Heart in Health and Disease Neumann, Joachim Hofmann, Britt Dhein, Stefan Gergs, Ulrich Int J Mol Sci Review Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects were strong, very modest, or absent, or even negative inotropic effects occurred. We can discern five dopamine receptors. In addition, the signal transduction by dopamine receptors and the regulation of the expression of cardiac dopamine receptors will be of interest to us, because this might be a tempting area of drug development. Dopamine acts in a species-dependent fashion on these cardiac dopamine receptors, but also on cardiac adrenergic receptors. We will discuss the utility of drugs that are currently available as tools to understand cardiac dopamine receptors. The molecule dopamine itself is present in the mammalian heart. Therefore, cardiac dopamine might act as an autocrine or paracrine compound in the mammalian heart. Dopamine itself might cause cardiac diseases. Moreover, the cardiac function of dopamine and the expression of dopamine receptors in the heart can be altered in diseases such as sepsis. Various drugs for cardiac and non-cardiac diseases are currently in the clinic that are, at least in part, agonists or antagonists at dopamine receptors. We define the research needs in order to understand dopamine receptors in the heart better. All in all, an update on the role of dopamine receptors in the human heart appears to be clinically relevant, and is thus presented here. MDPI 2023-03-06 /pmc/articles/PMC10003060/ /pubmed/36902474 http://dx.doi.org/10.3390/ijms24055042 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Neumann, Joachim
Hofmann, Britt
Dhein, Stefan
Gergs, Ulrich
Role of Dopamine in the Heart in Health and Disease
title Role of Dopamine in the Heart in Health and Disease
title_full Role of Dopamine in the Heart in Health and Disease
title_fullStr Role of Dopamine in the Heart in Health and Disease
title_full_unstemmed Role of Dopamine in the Heart in Health and Disease
title_short Role of Dopamine in the Heart in Health and Disease
title_sort role of dopamine in the heart in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003060/
https://www.ncbi.nlm.nih.gov/pubmed/36902474
http://dx.doi.org/10.3390/ijms24055042
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