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Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?

Acute and chronic corticosterone (CS) elevations after traumatic brain injury (TBI) may be involved in distant hippocampal damage and the development of late posttraumatic behavioral pathology. CS-dependent behavioral and morphological changes were studied 3 months after TBI induced by lateral fluid...

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Autores principales: Komoltsev, Ilia, Shalneva, Daria, Kostyunina, Olga, Volkova, Aleksandra, Frankevich, Stepan, Shirobokova, Natalia, Belikova, Anastasia, Balan, Sofia, Chizhova, Olesya, Salyp, Olga, Bashkatova, Daria, Kostrukov, Pavel, Soloveva, Aleksandra, Novikova, Margarita, Gulyaeva, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003069/
https://www.ncbi.nlm.nih.gov/pubmed/36901972
http://dx.doi.org/10.3390/ijms24054542
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author Komoltsev, Ilia
Shalneva, Daria
Kostyunina, Olga
Volkova, Aleksandra
Frankevich, Stepan
Shirobokova, Natalia
Belikova, Anastasia
Balan, Sofia
Chizhova, Olesya
Salyp, Olga
Bashkatova, Daria
Kostrukov, Pavel
Soloveva, Aleksandra
Novikova, Margarita
Gulyaeva, Natalia
author_facet Komoltsev, Ilia
Shalneva, Daria
Kostyunina, Olga
Volkova, Aleksandra
Frankevich, Stepan
Shirobokova, Natalia
Belikova, Anastasia
Balan, Sofia
Chizhova, Olesya
Salyp, Olga
Bashkatova, Daria
Kostrukov, Pavel
Soloveva, Aleksandra
Novikova, Margarita
Gulyaeva, Natalia
author_sort Komoltsev, Ilia
collection PubMed
description Acute and chronic corticosterone (CS) elevations after traumatic brain injury (TBI) may be involved in distant hippocampal damage and the development of late posttraumatic behavioral pathology. CS-dependent behavioral and morphological changes were studied 3 months after TBI induced by lateral fluid percussion in 51 male Sprague–Dawley rats. CS was measured in the background 3 and 7 days and 1, 2 and 3 months after TBI. Tests including open field, elevated plus maze, object location, new object recognition tests (NORT) and Barnes maze with reversal learning were used to assess behavioral changes in acute and late TBI periods. The elevation of CS on day 3 after TBI was accompanied by early CS-dependent objective memory impairments detected in NORT. Blood CS levels > 860 nmol/L predicted delayed mortality with an accuracy of 0.947. Ipsilateral neuronal loss in the hippocampal dentate gyrus, microgliosis in the contralateral dentate gyrus and bilateral thinning of hippocampal cell layers as well as delayed spatial memory deficits in the Barnes maze were revealed 3 months after TBI. Because only animals with moderate but not severe posttraumatic CS elevation survived, we suggest that moderate late posttraumatic morphological and behavioral deficits may be at least partially masked by CS-dependent survivorship bias.
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spelling pubmed-100030692023-03-11 Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias? Komoltsev, Ilia Shalneva, Daria Kostyunina, Olga Volkova, Aleksandra Frankevich, Stepan Shirobokova, Natalia Belikova, Anastasia Balan, Sofia Chizhova, Olesya Salyp, Olga Bashkatova, Daria Kostrukov, Pavel Soloveva, Aleksandra Novikova, Margarita Gulyaeva, Natalia Int J Mol Sci Article Acute and chronic corticosterone (CS) elevations after traumatic brain injury (TBI) may be involved in distant hippocampal damage and the development of late posttraumatic behavioral pathology. CS-dependent behavioral and morphological changes were studied 3 months after TBI induced by lateral fluid percussion in 51 male Sprague–Dawley rats. CS was measured in the background 3 and 7 days and 1, 2 and 3 months after TBI. Tests including open field, elevated plus maze, object location, new object recognition tests (NORT) and Barnes maze with reversal learning were used to assess behavioral changes in acute and late TBI periods. The elevation of CS on day 3 after TBI was accompanied by early CS-dependent objective memory impairments detected in NORT. Blood CS levels > 860 nmol/L predicted delayed mortality with an accuracy of 0.947. Ipsilateral neuronal loss in the hippocampal dentate gyrus, microgliosis in the contralateral dentate gyrus and bilateral thinning of hippocampal cell layers as well as delayed spatial memory deficits in the Barnes maze were revealed 3 months after TBI. Because only animals with moderate but not severe posttraumatic CS elevation survived, we suggest that moderate late posttraumatic morphological and behavioral deficits may be at least partially masked by CS-dependent survivorship bias. MDPI 2023-02-25 /pmc/articles/PMC10003069/ /pubmed/36901972 http://dx.doi.org/10.3390/ijms24054542 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Komoltsev, Ilia
Shalneva, Daria
Kostyunina, Olga
Volkova, Aleksandra
Frankevich, Stepan
Shirobokova, Natalia
Belikova, Anastasia
Balan, Sofia
Chizhova, Olesya
Salyp, Olga
Bashkatova, Daria
Kostrukov, Pavel
Soloveva, Aleksandra
Novikova, Margarita
Gulyaeva, Natalia
Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?
title Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?
title_full Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?
title_fullStr Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?
title_full_unstemmed Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?
title_short Delayed TBI-Induced Neuronal Death in the Ipsilateral Hippocampus and Behavioral Deficits in Rats: Influence of Corticosterone-Dependent Survivorship Bias?
title_sort delayed tbi-induced neuronal death in the ipsilateral hippocampus and behavioral deficits in rats: influence of corticosterone-dependent survivorship bias?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003069/
https://www.ncbi.nlm.nih.gov/pubmed/36901972
http://dx.doi.org/10.3390/ijms24054542
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