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Sex Differences in Inflammation and Muscle Wasting in Aging and Disease

Only in recent years, thanks to a precision medicine-based approach, have treatments tailored to the sex of each patient emerged in clinical trials. In this regard, both striated muscle tissues present significant differences between the two sexes, which may have important consequences for diagnosis...

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Autores principales: Della Peruta, Chiara, Lozanoska-Ochser, Biliana, Renzini, Alessandra, Moresi, Viviana, Sanchez Riera, Carles, Bouché, Marina, Coletti, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003083/
https://www.ncbi.nlm.nih.gov/pubmed/36902081
http://dx.doi.org/10.3390/ijms24054651
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author Della Peruta, Chiara
Lozanoska-Ochser, Biliana
Renzini, Alessandra
Moresi, Viviana
Sanchez Riera, Carles
Bouché, Marina
Coletti, Dario
author_facet Della Peruta, Chiara
Lozanoska-Ochser, Biliana
Renzini, Alessandra
Moresi, Viviana
Sanchez Riera, Carles
Bouché, Marina
Coletti, Dario
author_sort Della Peruta, Chiara
collection PubMed
description Only in recent years, thanks to a precision medicine-based approach, have treatments tailored to the sex of each patient emerged in clinical trials. In this regard, both striated muscle tissues present significant differences between the two sexes, which may have important consequences for diagnosis and therapy in aging and chronic illness. In fact, preservation of muscle mass in disease conditions correlates with survival; however, sex should be considered when protocols for the maintenance of muscle mass are designed. One obvious difference is that men have more muscle than women. Moreover, the two sexes differ in inflammation parameters, particularly in response to infection and disease. Therefore, unsurprisingly, men and women respond differently to therapies. In this review, we present an up-to-date overview on what is known about sex differences in skeletal muscle physiology and disfunction, such as disuse atrophy, age-related sarcopenia, and cachexia. In addition, we summarize sex differences in inflammation which may underly the aforementioned conditions because pro-inflammatory cytokines deeply affect muscle homeostasis. The comparison of these three conditions and their sex-related bases is interesting because different forms of muscle atrophy share common mechanisms; for instance, those responsible for protein dismantling are similar although differing in terms of kinetics, severity, and regulatory mechanisms. In pre-clinical research, exploring sexual dimorphism in disease conditions could highlight new efficacious treatments or recommend implementation of an existing one. Any protective factors discovered in one sex could be exploited to achieve lower morbidity, reduce the severity of the disease, or avoid mortality in the opposite sex. Thus, the understanding of sex-dependent responses to different forms of muscle atrophy and inflammation is of pivotal importance to design innovative, tailored, and efficient interventions.
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spelling pubmed-100030832023-03-11 Sex Differences in Inflammation and Muscle Wasting in Aging and Disease Della Peruta, Chiara Lozanoska-Ochser, Biliana Renzini, Alessandra Moresi, Viviana Sanchez Riera, Carles Bouché, Marina Coletti, Dario Int J Mol Sci Review Only in recent years, thanks to a precision medicine-based approach, have treatments tailored to the sex of each patient emerged in clinical trials. In this regard, both striated muscle tissues present significant differences between the two sexes, which may have important consequences for diagnosis and therapy in aging and chronic illness. In fact, preservation of muscle mass in disease conditions correlates with survival; however, sex should be considered when protocols for the maintenance of muscle mass are designed. One obvious difference is that men have more muscle than women. Moreover, the two sexes differ in inflammation parameters, particularly in response to infection and disease. Therefore, unsurprisingly, men and women respond differently to therapies. In this review, we present an up-to-date overview on what is known about sex differences in skeletal muscle physiology and disfunction, such as disuse atrophy, age-related sarcopenia, and cachexia. In addition, we summarize sex differences in inflammation which may underly the aforementioned conditions because pro-inflammatory cytokines deeply affect muscle homeostasis. The comparison of these three conditions and their sex-related bases is interesting because different forms of muscle atrophy share common mechanisms; for instance, those responsible for protein dismantling are similar although differing in terms of kinetics, severity, and regulatory mechanisms. In pre-clinical research, exploring sexual dimorphism in disease conditions could highlight new efficacious treatments or recommend implementation of an existing one. Any protective factors discovered in one sex could be exploited to achieve lower morbidity, reduce the severity of the disease, or avoid mortality in the opposite sex. Thus, the understanding of sex-dependent responses to different forms of muscle atrophy and inflammation is of pivotal importance to design innovative, tailored, and efficient interventions. MDPI 2023-02-28 /pmc/articles/PMC10003083/ /pubmed/36902081 http://dx.doi.org/10.3390/ijms24054651 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Della Peruta, Chiara
Lozanoska-Ochser, Biliana
Renzini, Alessandra
Moresi, Viviana
Sanchez Riera, Carles
Bouché, Marina
Coletti, Dario
Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
title Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
title_full Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
title_fullStr Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
title_full_unstemmed Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
title_short Sex Differences in Inflammation and Muscle Wasting in Aging and Disease
title_sort sex differences in inflammation and muscle wasting in aging and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003083/
https://www.ncbi.nlm.nih.gov/pubmed/36902081
http://dx.doi.org/10.3390/ijms24054651
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