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Endoplasmic Reticulum Stress in Renal Cell Carcinoma
The endoplasmic reticulum is an organelle exerting crucial functions in protein production, metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and the capacity of this organelle to perform its normal functions is reduced. Subsequently, specific sign...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003093/ https://www.ncbi.nlm.nih.gov/pubmed/36902344 http://dx.doi.org/10.3390/ijms24054914 |
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author | Correia de Sousa, Marta Delangre, Etienne Türkal, Miranda Foti, Michelangelo Gjorgjieva, Monika |
author_facet | Correia de Sousa, Marta Delangre, Etienne Türkal, Miranda Foti, Michelangelo Gjorgjieva, Monika |
author_sort | Correia de Sousa, Marta |
collection | PubMed |
description | The endoplasmic reticulum is an organelle exerting crucial functions in protein production, metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and the capacity of this organelle to perform its normal functions is reduced. Subsequently, specific signaling cascades, together forming the so-called unfolded protein response, are activated and deeply impact cell fate. In normal renal cells, these molecular pathways strive to either resolve cell injury or activate cell death, depending on the extent of cell damage. Therefore, the activation of the endoplasmic reticulum stress pathway was suggested as an interesting therapeutic strategy for pathologies such as cancer. However, renal cancer cells are known to hijack these stress mechanisms and exploit them to their advantage in order to promote their survival through rewiring of their metabolism, activation of oxidative stress responses, autophagy, inhibition of apoptosis and senescence. Recent data strongly suggest that a certain threshold of endoplasmic reticulum stress activation needs to be attained in cancer cells in order to shift endoplasmic reticulum stress responses from a pro-survival to a pro-apoptotic outcome. Several endoplasmic reticulum stress pharmacological modulators of interest for therapeutic purposes are already available, but only a handful were tested in the case of renal carcinoma, and their effects in an in vivo setting remain poorly known. This review discusses the relevance of endoplasmic reticulum stress activation or suppression in renal cancer cell progression and the therapeutic potential of targeting this cellular process for this cancer. |
format | Online Article Text |
id | pubmed-10003093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100030932023-03-11 Endoplasmic Reticulum Stress in Renal Cell Carcinoma Correia de Sousa, Marta Delangre, Etienne Türkal, Miranda Foti, Michelangelo Gjorgjieva, Monika Int J Mol Sci Review The endoplasmic reticulum is an organelle exerting crucial functions in protein production, metabolism homeostasis and cell signaling. Endoplasmic reticulum stress occurs when cells are damaged and the capacity of this organelle to perform its normal functions is reduced. Subsequently, specific signaling cascades, together forming the so-called unfolded protein response, are activated and deeply impact cell fate. In normal renal cells, these molecular pathways strive to either resolve cell injury or activate cell death, depending on the extent of cell damage. Therefore, the activation of the endoplasmic reticulum stress pathway was suggested as an interesting therapeutic strategy for pathologies such as cancer. However, renal cancer cells are known to hijack these stress mechanisms and exploit them to their advantage in order to promote their survival through rewiring of their metabolism, activation of oxidative stress responses, autophagy, inhibition of apoptosis and senescence. Recent data strongly suggest that a certain threshold of endoplasmic reticulum stress activation needs to be attained in cancer cells in order to shift endoplasmic reticulum stress responses from a pro-survival to a pro-apoptotic outcome. Several endoplasmic reticulum stress pharmacological modulators of interest for therapeutic purposes are already available, but only a handful were tested in the case of renal carcinoma, and their effects in an in vivo setting remain poorly known. This review discusses the relevance of endoplasmic reticulum stress activation or suppression in renal cancer cell progression and the therapeutic potential of targeting this cellular process for this cancer. MDPI 2023-03-03 /pmc/articles/PMC10003093/ /pubmed/36902344 http://dx.doi.org/10.3390/ijms24054914 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Correia de Sousa, Marta Delangre, Etienne Türkal, Miranda Foti, Michelangelo Gjorgjieva, Monika Endoplasmic Reticulum Stress in Renal Cell Carcinoma |
title | Endoplasmic Reticulum Stress in Renal Cell Carcinoma |
title_full | Endoplasmic Reticulum Stress in Renal Cell Carcinoma |
title_fullStr | Endoplasmic Reticulum Stress in Renal Cell Carcinoma |
title_full_unstemmed | Endoplasmic Reticulum Stress in Renal Cell Carcinoma |
title_short | Endoplasmic Reticulum Stress in Renal Cell Carcinoma |
title_sort | endoplasmic reticulum stress in renal cell carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003093/ https://www.ncbi.nlm.nih.gov/pubmed/36902344 http://dx.doi.org/10.3390/ijms24054914 |
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