Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions

A convenient and practical method for the synthesis of bioactive ester-containing chroman-4-ones through the cascade radical cyclization of 2-(allyloxy)arylaldehydes and oxalates is described. The preliminary studies suggest that an alkoxycarbonyl radical might be involved in the current transformat...

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Detalles Bibliográficos
Autores principales: Peng, Sha, Liu, Jiao, Jiang, Ze-Qun, Yuan, Lin, Liu, Xiao-Wen, Xie, Long-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003100/
https://www.ncbi.nlm.nih.gov/pubmed/36902464
http://dx.doi.org/10.3390/ijms24055028
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author Peng, Sha
Liu, Jiao
Jiang, Ze-Qun
Yuan, Lin
Liu, Xiao-Wen
Xie, Long-Yong
author_facet Peng, Sha
Liu, Jiao
Jiang, Ze-Qun
Yuan, Lin
Liu, Xiao-Wen
Xie, Long-Yong
author_sort Peng, Sha
collection PubMed
description A convenient and practical method for the synthesis of bioactive ester-containing chroman-4-ones through the cascade radical cyclization of 2-(allyloxy)arylaldehydes and oxalates is described. The preliminary studies suggest that an alkoxycarbonyl radical might be involved in the current transformation, which was generated via the decarboxylation of oxalates in the presence of (NH(4))(2)S(2)O(8).
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spelling pubmed-100031002023-03-11 Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions Peng, Sha Liu, Jiao Jiang, Ze-Qun Yuan, Lin Liu, Xiao-Wen Xie, Long-Yong Int J Mol Sci Article A convenient and practical method for the synthesis of bioactive ester-containing chroman-4-ones through the cascade radical cyclization of 2-(allyloxy)arylaldehydes and oxalates is described. The preliminary studies suggest that an alkoxycarbonyl radical might be involved in the current transformation, which was generated via the decarboxylation of oxalates in the presence of (NH(4))(2)S(2)O(8). MDPI 2023-03-06 /pmc/articles/PMC10003100/ /pubmed/36902464 http://dx.doi.org/10.3390/ijms24055028 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peng, Sha
Liu, Jiao
Jiang, Ze-Qun
Yuan, Lin
Liu, Xiao-Wen
Xie, Long-Yong
Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions
title Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions
title_full Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions
title_fullStr Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions
title_full_unstemmed Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions
title_short Synthesis of Ester-Containing Chroman-4-Ones via Cascade Radical Annulation of 2-(Allyloxy)Arylaldehydes with Oxalates under Metal Free Conditions
title_sort synthesis of ester-containing chroman-4-ones via cascade radical annulation of 2-(allyloxy)arylaldehydes with oxalates under metal free conditions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003100/
https://www.ncbi.nlm.nih.gov/pubmed/36902464
http://dx.doi.org/10.3390/ijms24055028
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