Cargando…
Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt
Background: Children with chronic kidney disease (CKD), particularly those who require hemodialysis (HD), are at high risk of hepatitis B virus (HBV) infection. The HBV vaccine non-/hypo-response rate among HD children remains high, and it is critical to investigate the influencing factors and their...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003117/ https://www.ncbi.nlm.nih.gov/pubmed/36902652 http://dx.doi.org/10.3390/jcm12051864 |
_version_ | 1784904534635577344 |
---|---|
author | Youssef, Doaa Mohammed El-Shal, Amal S. Elbehidy, Rabab M. Fouda, Mohamed Adel Shalaby, Sally M. El Hawy, Lamiaa Lotfy Elsadek, Abdelrahman Fathi Neemat-Allah, Mayy Abd Alfattah Ramadan, Seham M. Gohary, Amal Arab, Faika Alsharkawy, Mona Tolba, Sabry Abdel Rahman Abdelsalam, Mohamed Mohamed Amin, Ezzat Kamel Gehad, Mona Hamed |
author_facet | Youssef, Doaa Mohammed El-Shal, Amal S. Elbehidy, Rabab M. Fouda, Mohamed Adel Shalaby, Sally M. El Hawy, Lamiaa Lotfy Elsadek, Abdelrahman Fathi Neemat-Allah, Mayy Abd Alfattah Ramadan, Seham M. Gohary, Amal Arab, Faika Alsharkawy, Mona Tolba, Sabry Abdel Rahman Abdelsalam, Mohamed Mohamed Amin, Ezzat Kamel Gehad, Mona Hamed |
author_sort | Youssef, Doaa Mohammed |
collection | PubMed |
description | Background: Children with chronic kidney disease (CKD), particularly those who require hemodialysis (HD), are at high risk of hepatitis B virus (HBV) infection. The HBV vaccine non-/hypo-response rate among HD children remains high, and it is critical to investigate the influencing factors and their linkages. The aim of this study was to identify the pattern of HB vaccination response in HD children and to analyze the interference of various clinical and biomedical factors with the immunological response to HB vaccination. Methods: This cross-sectional study included 74 children on maintenance hemodialysis, aged between 3 and 18 years. These children were subjected to complete clinical examination and laboratory investigations. Results: Out of a total of 74 children with HD, 25 (33.8%) were positive for the HCV antibody. Regarding the immunological response to hepatitis B vaccine, 70% were non-/hypo-responders (≤100 IU/mL) and only 30% mounted a high-level response (more than 100 IU/mL). There was a significant relation between non-/hypo-response and sex, dialysis duration, and HCV infection. Being on dialysis for more than 5 years and being HCV Ab-positive were independent variables for non-/hypo-response to HB vaccine. Conclusions: Children with CKD on regular HD have poor seroconversion rates in response to the HBV vaccine, which were influenced by dialysis duration and HCV infection. |
format | Online Article Text |
id | pubmed-10003117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100031172023-03-11 Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt Youssef, Doaa Mohammed El-Shal, Amal S. Elbehidy, Rabab M. Fouda, Mohamed Adel Shalaby, Sally M. El Hawy, Lamiaa Lotfy Elsadek, Abdelrahman Fathi Neemat-Allah, Mayy Abd Alfattah Ramadan, Seham M. Gohary, Amal Arab, Faika Alsharkawy, Mona Tolba, Sabry Abdel Rahman Abdelsalam, Mohamed Mohamed Amin, Ezzat Kamel Gehad, Mona Hamed J Clin Med Article Background: Children with chronic kidney disease (CKD), particularly those who require hemodialysis (HD), are at high risk of hepatitis B virus (HBV) infection. The HBV vaccine non-/hypo-response rate among HD children remains high, and it is critical to investigate the influencing factors and their linkages. The aim of this study was to identify the pattern of HB vaccination response in HD children and to analyze the interference of various clinical and biomedical factors with the immunological response to HB vaccination. Methods: This cross-sectional study included 74 children on maintenance hemodialysis, aged between 3 and 18 years. These children were subjected to complete clinical examination and laboratory investigations. Results: Out of a total of 74 children with HD, 25 (33.8%) were positive for the HCV antibody. Regarding the immunological response to hepatitis B vaccine, 70% were non-/hypo-responders (≤100 IU/mL) and only 30% mounted a high-level response (more than 100 IU/mL). There was a significant relation between non-/hypo-response and sex, dialysis duration, and HCV infection. Being on dialysis for more than 5 years and being HCV Ab-positive were independent variables for non-/hypo-response to HB vaccine. Conclusions: Children with CKD on regular HD have poor seroconversion rates in response to the HBV vaccine, which were influenced by dialysis duration and HCV infection. MDPI 2023-02-27 /pmc/articles/PMC10003117/ /pubmed/36902652 http://dx.doi.org/10.3390/jcm12051864 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Youssef, Doaa Mohammed El-Shal, Amal S. Elbehidy, Rabab M. Fouda, Mohamed Adel Shalaby, Sally M. El Hawy, Lamiaa Lotfy Elsadek, Abdelrahman Fathi Neemat-Allah, Mayy Abd Alfattah Ramadan, Seham M. Gohary, Amal Arab, Faika Alsharkawy, Mona Tolba, Sabry Abdel Rahman Abdelsalam, Mohamed Mohamed Amin, Ezzat Kamel Gehad, Mona Hamed Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt |
title | Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt |
title_full | Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt |
title_fullStr | Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt |
title_full_unstemmed | Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt |
title_short | Hepatitis B Immunization Status in Children with Chronic Kidney Disease: Experience at a Single Center, Egypt |
title_sort | hepatitis b immunization status in children with chronic kidney disease: experience at a single center, egypt |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003117/ https://www.ncbi.nlm.nih.gov/pubmed/36902652 http://dx.doi.org/10.3390/jcm12051864 |
work_keys_str_mv | AT youssefdoaamohammed hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT elshalamals hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT elbehidyrababm hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT foudamohamedadel hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT shalabysallym hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT elhawylamiaalotfy hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT elsadekabdelrahmanfathi hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT neematallahmayyabdalfattah hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT ramadansehamm hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT goharyamal hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT arabfaika hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT alsharkawymona hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT tolbasabryabdelrahman hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT abdelsalammohamedmohamed hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT aminezzatkamel hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt AT gehadmonahamed hepatitisbimmunizationstatusinchildrenwithchronickidneydiseaseexperienceatasinglecenteregypt |