Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin

Calcium/calmodulin (CaM)-dependent protein kinase kinase 2 (CaMKK2) regulates bone remodeling through its effects on osteoblasts and osteoclasts. However, its role in osteocytes, the most abundant bone cell type and the master regulator of bone remodeling, remains unknown. Here we report that the co...

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Detalles Bibliográficos
Autores principales: Williams, Justin N., Irwin, Mavis, Li, Yong, Kambrath, Anuradha Valiya, Mattingly, Brett T., Patel, Sheel, Kittaka, Mizuho, Collins, Rebecca N., Clough, Nicholas A., Doud, Emma H., Mosley, Amber L., Bellido, Teresita, Bruzzaniti, Angela, Plotkin, Lilian I., Trinidad, Jonathan C., Thompson, William R., Bonewald, Lynda F., Sankar, Uma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003151/
https://www.ncbi.nlm.nih.gov/pubmed/36902150
http://dx.doi.org/10.3390/ijms24054718

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