Cargando…

Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign

Prostate cancer (PCa) is the most common non-cutaneous malignancy in men worldwide, and it represents the fifth leading cause of death. It has long been recognized that dietary habits can impact prostate health and improve the benefits of traditional medical care. The activity of novel agents on pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Crocetto, Felice, Barone, Biagio, D’Aguanno, Giulio, Falcone, Alfonso, de Vivo, Rosamaria, Rienzo, Monica, Recchia, Laura, Di Zazzo, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003229/
https://www.ncbi.nlm.nih.gov/pubmed/36902619
http://dx.doi.org/10.3390/jcm12051831
_version_ 1784904556073713664
author Crocetto, Felice
Barone, Biagio
D’Aguanno, Giulio
Falcone, Alfonso
de Vivo, Rosamaria
Rienzo, Monica
Recchia, Laura
Di Zazzo, Erika
author_facet Crocetto, Felice
Barone, Biagio
D’Aguanno, Giulio
Falcone, Alfonso
de Vivo, Rosamaria
Rienzo, Monica
Recchia, Laura
Di Zazzo, Erika
author_sort Crocetto, Felice
collection PubMed
description Prostate cancer (PCa) is the most common non-cutaneous malignancy in men worldwide, and it represents the fifth leading cause of death. It has long been recognized that dietary habits can impact prostate health and improve the benefits of traditional medical care. The activity of novel agents on prostate health is routinely assessed by measuring changes in serum prostate-specific antigen (PSA) levels. Recent studies hypothesized that vitamin D supplementation reduces circulating androgen levels and PSA secretion, inhibits cell growth of the hormone-sensitive PCa cell lines, counteracts neoangiogenesis and improves apoptosis. However, the results are conflicting and inconsistent. Furthermore, the use of vitamin D in PCa treatments has not achieved consistently positive results to date. In order to assess the existence of a correlation between the PSA and 25(OH)vitamin D levels as widely hypothesized in the literature, we analyzed the serum PSA and 25(OH)vitamin D concentration on a cohort of one hundred patients joining a PCa screening campaign. Additionally, we performed medical and pharmacological anamnesis and analyzed lifestyle, as sport practice and eating habits, by administering a questionnaire on family history. Although several studies suggested a protective role of vitamin D in PCa onset prevention and progression, our preliminary results revealed a clear absence of correlation between the serum vitamin D and PSA concentration levels, suggesting that vitamin D has no impact on PCa risk. Further investigations enrolling a huge number of patients are needed with particular attention to vitamin D supplementation, calcium intake, solar radiation that influences vitamin D metabolism and other potential indicators of health to confirm the absence of correlation observed in our study.
format Online
Article
Text
id pubmed-10003229
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100032292023-03-11 Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign Crocetto, Felice Barone, Biagio D’Aguanno, Giulio Falcone, Alfonso de Vivo, Rosamaria Rienzo, Monica Recchia, Laura Di Zazzo, Erika J Clin Med Article Prostate cancer (PCa) is the most common non-cutaneous malignancy in men worldwide, and it represents the fifth leading cause of death. It has long been recognized that dietary habits can impact prostate health and improve the benefits of traditional medical care. The activity of novel agents on prostate health is routinely assessed by measuring changes in serum prostate-specific antigen (PSA) levels. Recent studies hypothesized that vitamin D supplementation reduces circulating androgen levels and PSA secretion, inhibits cell growth of the hormone-sensitive PCa cell lines, counteracts neoangiogenesis and improves apoptosis. However, the results are conflicting and inconsistent. Furthermore, the use of vitamin D in PCa treatments has not achieved consistently positive results to date. In order to assess the existence of a correlation between the PSA and 25(OH)vitamin D levels as widely hypothesized in the literature, we analyzed the serum PSA and 25(OH)vitamin D concentration on a cohort of one hundred patients joining a PCa screening campaign. Additionally, we performed medical and pharmacological anamnesis and analyzed lifestyle, as sport practice and eating habits, by administering a questionnaire on family history. Although several studies suggested a protective role of vitamin D in PCa onset prevention and progression, our preliminary results revealed a clear absence of correlation between the serum vitamin D and PSA concentration levels, suggesting that vitamin D has no impact on PCa risk. Further investigations enrolling a huge number of patients are needed with particular attention to vitamin D supplementation, calcium intake, solar radiation that influences vitamin D metabolism and other potential indicators of health to confirm the absence of correlation observed in our study. MDPI 2023-02-24 /pmc/articles/PMC10003229/ /pubmed/36902619 http://dx.doi.org/10.3390/jcm12051831 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Crocetto, Felice
Barone, Biagio
D’Aguanno, Giulio
Falcone, Alfonso
de Vivo, Rosamaria
Rienzo, Monica
Recchia, Laura
Di Zazzo, Erika
Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign
title Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign
title_full Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign
title_fullStr Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign
title_full_unstemmed Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign
title_short Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign
title_sort vitamin d, a regulator of androgen levels, is not correlated to psa serum levels in a cohort of the middle italy region participating to a prostate cancer screening campaign
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003229/
https://www.ncbi.nlm.nih.gov/pubmed/36902619
http://dx.doi.org/10.3390/jcm12051831
work_keys_str_mv AT crocettofelice vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT baronebiagio vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT daguannogiulio vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT falconealfonso vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT devivorosamaria vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT rienzomonica vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT recchialaura vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign
AT dizazzoerika vitamindaregulatorofandrogenlevelsisnotcorrelatedtopsaserumlevelsinacohortofthemiddleitalyregionparticipatingtoaprostatecancerscreeningcampaign