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The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease

The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling process. In addition to glucose, the main nutrient for the osteoblast lineages, recent data highlight the importance of amino acid and fatty acid...

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Detalles Bibliográficos
Autores principales: Lungu, Oxana, Toscani, Denise, Burroughs-Garcia, Jessica, Giuliani, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003241/
https://www.ncbi.nlm.nih.gov/pubmed/36902326
http://dx.doi.org/10.3390/ijms24054893
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author Lungu, Oxana
Toscani, Denise
Burroughs-Garcia, Jessica
Giuliani, Nicola
author_facet Lungu, Oxana
Toscani, Denise
Burroughs-Garcia, Jessica
Giuliani, Nicola
author_sort Lungu, Oxana
collection PubMed
description The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling process. In addition to glucose, the main nutrient for the osteoblast lineages, recent data highlight the importance of amino acid and fatty acid metabolism in providing the fuel necessary for the proper functioning of OBs. Among the amino acids, it has been reported that OBs are largely dependent on glutamine (Gln) for their differentiation and activity. In this review, we describe the main metabolic pathways governing OBs’ fate and functions, both in physiological and pathological malignant conditions. In particular, we focus on multiple myeloma (MM) bone disease, which is characterized by a severe imbalance in OB differentiation due to the presence of malignant plasma cells into the bone microenvironment. Here, we describe the most important metabolic alterations involved in the inhibition of OB formation and activity in MM patients.
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spelling pubmed-100032412023-03-11 The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease Lungu, Oxana Toscani, Denise Burroughs-Garcia, Jessica Giuliani, Nicola Int J Mol Sci Review The study of osteoblast (OB) metabolism has recently received increased attention due to the considerable amount of energy used during the bone remodeling process. In addition to glucose, the main nutrient for the osteoblast lineages, recent data highlight the importance of amino acid and fatty acid metabolism in providing the fuel necessary for the proper functioning of OBs. Among the amino acids, it has been reported that OBs are largely dependent on glutamine (Gln) for their differentiation and activity. In this review, we describe the main metabolic pathways governing OBs’ fate and functions, both in physiological and pathological malignant conditions. In particular, we focus on multiple myeloma (MM) bone disease, which is characterized by a severe imbalance in OB differentiation due to the presence of malignant plasma cells into the bone microenvironment. Here, we describe the most important metabolic alterations involved in the inhibition of OB formation and activity in MM patients. MDPI 2023-03-03 /pmc/articles/PMC10003241/ /pubmed/36902326 http://dx.doi.org/10.3390/ijms24054893 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lungu, Oxana
Toscani, Denise
Burroughs-Garcia, Jessica
Giuliani, Nicola
The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
title The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
title_full The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
title_fullStr The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
title_full_unstemmed The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
title_short The Metabolic Features of Osteoblasts: Implications for Multiple Myeloma (MM) Bone Disease
title_sort metabolic features of osteoblasts: implications for multiple myeloma (mm) bone disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003241/
https://www.ncbi.nlm.nih.gov/pubmed/36902326
http://dx.doi.org/10.3390/ijms24054893
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