Structural Characterization of Hypoxia Inducible Factor α—Prolyl Hydroxylase Domain 2 Interaction through MD Simulations

The Prolyl Hydroxylases (PHDs) are an enzymatic family that regulates cell oxygen-sensing. PHDs hydroxylate hypoxia-inducible transcription factors α (HIFs-α) driving their proteasomal degradation. Hypoxia inhibits PHDs activity, inducing HIFs-α stabilization and cell adaptation to hypoxia. As a hal...

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Detalles Bibliográficos
Autores principales: Camagni, Giorgia F., Minervini, Giovanni, Tosatto, Silvio C. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003257/
https://www.ncbi.nlm.nih.gov/pubmed/36902141
http://dx.doi.org/10.3390/ijms24054710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003257/
https://www.ncbi.nlm.nih.gov/pubmed/36902141
http://dx.doi.org/10.3390/ijms24054710

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