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Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer

The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unknown, we previously showed that a shorter allele (ger...

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Autores principales: Honma, Naoko, Arai, Tomio, Matsuda, Yoko, Fukunaga, Yosuke, Muramatsu, Masaaki, Ikeda, Shinobu, Akishima-Fukasawa, Yuri, Yamamoto, Noriko, Kawachi, Hiroshi, Ishikawa, Yuichi, Takeuchi, Kengo, Mikami, Tetuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003297/
https://www.ncbi.nlm.nih.gov/pubmed/36901930
http://dx.doi.org/10.3390/ijms24054502
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author Honma, Naoko
Arai, Tomio
Matsuda, Yoko
Fukunaga, Yosuke
Muramatsu, Masaaki
Ikeda, Shinobu
Akishima-Fukasawa, Yuri
Yamamoto, Noriko
Kawachi, Hiroshi
Ishikawa, Yuichi
Takeuchi, Kengo
Mikami, Tetuo
author_facet Honma, Naoko
Arai, Tomio
Matsuda, Yoko
Fukunaga, Yosuke
Muramatsu, Masaaki
Ikeda, Shinobu
Akishima-Fukasawa, Yuri
Yamamoto, Noriko
Kawachi, Hiroshi
Ishikawa, Yuichi
Takeuchi, Kengo
Mikami, Tetuo
author_sort Honma, Naoko
collection PubMed
description The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unknown, we previously showed that a shorter allele (germline) increased the risk of colon cancer in older women, whereas it decreased it in younger postmenopausal women. ESR2-CA and ER-β expressions were examined in cancerous (Ca) and non-cancerous (NonCa) tissue pairs from 114 postmenopausal women, and comparisons were made considering tissue types, age/locus, and the mismatch repair protein (MMR) status. ESR2-CA repeats <22/≥22 were designated as ‘S’/‘L’, respectively, resulting in genotypes SS/nSS (=SL&LL). In NonCa, the rate of the SS genotype and ER-β expression level were significantly higher in right-sided cases of women ≥70 (≥70Rt) than in those in the others. A decreased ER-β expression in Ca compared with NonCa was observed in proficient-MMR, but not in deficient-MMR. In NonCa, but not in Ca, ER-β expression was significantly higher in SS than in nSS. ≥70Rt cases were characterized by NonCa with a high rate of SS genotype or high ER-β expression. The germline ESR2-CA genotype and resulting ER-β expression were considered to affect the clinical characteristics (age/locus/MMR status) of colon cancer, supporting our previous findings.
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spelling pubmed-100032972023-03-11 Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer Honma, Naoko Arai, Tomio Matsuda, Yoko Fukunaga, Yosuke Muramatsu, Masaaki Ikeda, Shinobu Akishima-Fukasawa, Yuri Yamamoto, Noriko Kawachi, Hiroshi Ishikawa, Yuichi Takeuchi, Kengo Mikami, Tetuo Int J Mol Sci Article The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its function is unknown, we previously showed that a shorter allele (germline) increased the risk of colon cancer in older women, whereas it decreased it in younger postmenopausal women. ESR2-CA and ER-β expressions were examined in cancerous (Ca) and non-cancerous (NonCa) tissue pairs from 114 postmenopausal women, and comparisons were made considering tissue types, age/locus, and the mismatch repair protein (MMR) status. ESR2-CA repeats <22/≥22 were designated as ‘S’/‘L’, respectively, resulting in genotypes SS/nSS (=SL&LL). In NonCa, the rate of the SS genotype and ER-β expression level were significantly higher in right-sided cases of women ≥70 (≥70Rt) than in those in the others. A decreased ER-β expression in Ca compared with NonCa was observed in proficient-MMR, but not in deficient-MMR. In NonCa, but not in Ca, ER-β expression was significantly higher in SS than in nSS. ≥70Rt cases were characterized by NonCa with a high rate of SS genotype or high ER-β expression. The germline ESR2-CA genotype and resulting ER-β expression were considered to affect the clinical characteristics (age/locus/MMR status) of colon cancer, supporting our previous findings. MDPI 2023-02-24 /pmc/articles/PMC10003297/ /pubmed/36901930 http://dx.doi.org/10.3390/ijms24054502 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Honma, Naoko
Arai, Tomio
Matsuda, Yoko
Fukunaga, Yosuke
Muramatsu, Masaaki
Ikeda, Shinobu
Akishima-Fukasawa, Yuri
Yamamoto, Noriko
Kawachi, Hiroshi
Ishikawa, Yuichi
Takeuchi, Kengo
Mikami, Tetuo
Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
title Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
title_full Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
title_fullStr Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
title_full_unstemmed Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
title_short Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
title_sort estrogen receptor-β gene cytosine-adenine (esr2-ca) repeat polymorphism in postmenopausal colon cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003297/
https://www.ncbi.nlm.nih.gov/pubmed/36901930
http://dx.doi.org/10.3390/ijms24054502
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