Frontline Sodium Channel-Blocking Antiseizure Medicine Use Promotes Future Onset of Drug-Resistant Chronic Seizures

The mechanisms of treatment-resistant epilepsy remain unclear. We have previously shown that frontline administration of therapeutic doses of lamotrigine (LTG), which preferentially inhibits the fast-inactivation state of sodium channels, during corneal kindling of mice promotes cross-resistance to...

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Detalles Bibliográficos
Autores principales: Zierath, Dannielle, Mizuno, Stephanie, Barker-Haliski, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003379/
https://www.ncbi.nlm.nih.gov/pubmed/36902275
http://dx.doi.org/10.3390/ijms24054848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003379/
https://www.ncbi.nlm.nih.gov/pubmed/36902275
http://dx.doi.org/10.3390/ijms24054848

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