Cargando…
Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature
Immunotherapy in oncology is replacing traditional therapies due to it specific action and limited side effects. Despite the high efficacy of immunotherapy, side effects such as bacterial infection have been reported. Bacterial skin and soft tissue infections represent one of the most important diff...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003408/ https://www.ncbi.nlm.nih.gov/pubmed/36902013 http://dx.doi.org/10.3390/ijms24054580 |
_version_ | 1784904600404361216 |
---|---|
author | Cosio, Terenzio Coniglione, Filadelfo Flaminio, Valeria Gaziano, Roberta Coletta, Deborah Petruccelli, Rosalba Dika, Emi Bianchi, Luca Campione, Elena |
author_facet | Cosio, Terenzio Coniglione, Filadelfo Flaminio, Valeria Gaziano, Roberta Coletta, Deborah Petruccelli, Rosalba Dika, Emi Bianchi, Luca Campione, Elena |
author_sort | Cosio, Terenzio |
collection | PubMed |
description | Immunotherapy in oncology is replacing traditional therapies due to it specific action and limited side effects. Despite the high efficacy of immunotherapy, side effects such as bacterial infection have been reported. Bacterial skin and soft tissue infections represent one of the most important differential diagnoses in patients presenting with reddened and swollen skin and soft tissue. Among these infections, cellulitis (phlegmon) and abscesses are the most frequent. In most cases, these infections occur locally with possible contiguous spread, or as a multifocal manifestation, especially in immunocompromised patients. Herein, we report a case of pyodermitis in an immunocompromised district in a patient treated with nivolumab for non-small cell lung cancer. A 64-year-old, smoker male patient showed cutaneous lesions at a different evolution level in the left arm, all in a tattooed area, with one phlegmon and two ulcerated lesions. Microbiological cultures and gram staining revealed an infection caused by a methicillin-susceptible but erythromycin-resistant (ER-R), clindamycin-resistant (CL-R), and gentamicin-resistant (GE-R) Staphylococcus aureus strain. Despite immunotherapy becoming a milestone in oncologic treatment, more than the spectrum of immune-mediated toxicities of these agents needs to be investigated. This report highlights the importance of considering lifestyle and cutaneous background before starting immunotherapy for cancer treatment, with an emphasis on pharmacogenomics and the possibility of modified skin microbiota predisposing to cutaneous infections in patients treated with PD-1 inhibitors. |
format | Online Article Text |
id | pubmed-10003408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100034082023-03-11 Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature Cosio, Terenzio Coniglione, Filadelfo Flaminio, Valeria Gaziano, Roberta Coletta, Deborah Petruccelli, Rosalba Dika, Emi Bianchi, Luca Campione, Elena Int J Mol Sci Case Report Immunotherapy in oncology is replacing traditional therapies due to it specific action and limited side effects. Despite the high efficacy of immunotherapy, side effects such as bacterial infection have been reported. Bacterial skin and soft tissue infections represent one of the most important differential diagnoses in patients presenting with reddened and swollen skin and soft tissue. Among these infections, cellulitis (phlegmon) and abscesses are the most frequent. In most cases, these infections occur locally with possible contiguous spread, or as a multifocal manifestation, especially in immunocompromised patients. Herein, we report a case of pyodermitis in an immunocompromised district in a patient treated with nivolumab for non-small cell lung cancer. A 64-year-old, smoker male patient showed cutaneous lesions at a different evolution level in the left arm, all in a tattooed area, with one phlegmon and two ulcerated lesions. Microbiological cultures and gram staining revealed an infection caused by a methicillin-susceptible but erythromycin-resistant (ER-R), clindamycin-resistant (CL-R), and gentamicin-resistant (GE-R) Staphylococcus aureus strain. Despite immunotherapy becoming a milestone in oncologic treatment, more than the spectrum of immune-mediated toxicities of these agents needs to be investigated. This report highlights the importance of considering lifestyle and cutaneous background before starting immunotherapy for cancer treatment, with an emphasis on pharmacogenomics and the possibility of modified skin microbiota predisposing to cutaneous infections in patients treated with PD-1 inhibitors. MDPI 2023-02-26 /pmc/articles/PMC10003408/ /pubmed/36902013 http://dx.doi.org/10.3390/ijms24054580 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Cosio, Terenzio Coniglione, Filadelfo Flaminio, Valeria Gaziano, Roberta Coletta, Deborah Petruccelli, Rosalba Dika, Emi Bianchi, Luca Campione, Elena Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature |
title | Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature |
title_full | Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature |
title_fullStr | Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature |
title_full_unstemmed | Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature |
title_short | Pyodermitis during Nivolumab Treatment for Non-Small Cell Lung Cancer: A Case Report and Review of the Literature |
title_sort | pyodermitis during nivolumab treatment for non-small cell lung cancer: a case report and review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003408/ https://www.ncbi.nlm.nih.gov/pubmed/36902013 http://dx.doi.org/10.3390/ijms24054580 |
work_keys_str_mv | AT cosioterenzio pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT coniglionefiladelfo pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT flaminiovaleria pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT gazianoroberta pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT colettadeborah pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT petruccellirosalba pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT dikaemi pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT bianchiluca pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature AT campioneelena pyodermitisduringnivolumabtreatmentfornonsmallcelllungcanceracasereportandreviewoftheliterature |