Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice

BG45 is a class Ⅰ histone deacetylase inhibitor (HDACI) with selectivity for HDAC3. Our previous study demonstrated that BG45 can upregulate the expression of synaptic proteins and reduce the loss of neurons in the hippocampus of APPswe/PS1dE9 (APP/PS1) transgenic mice (Tg). The entorhinal cortex is...

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Detalles Bibliográficos
Autores principales: Wang, Chunyang, Shen, Di, Hu, Yingqiu, Chen, Jie, Liu, Jingyun, Huang, Yufei, Yu, Xuebin, Chu, Haiying, Zhang, Chenghong, Yin, Liangwei, Liu, Yi, Ma, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003411/
https://www.ncbi.nlm.nih.gov/pubmed/36902234
http://dx.doi.org/10.3390/ijms24054805

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