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Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study

SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of ap...

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Autores principales: Begue, Floran, Chemello, Kévin, Veeren, Bryan, Lortat-Jacob, Brice, Tran-Dinh, Alexy, Zappella, Nathalie, Snauwaert, Aurelie, Robert, Tiphaine, Rondeau, Philippe, Lagrange-Xelot, Marie, Montravers, Philippe, Couret, David, Tanaka, Sébastien, Meilhac, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003429/
https://www.ncbi.nlm.nih.gov/pubmed/36902035
http://dx.doi.org/10.3390/ijms24054605
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author Begue, Floran
Chemello, Kévin
Veeren, Bryan
Lortat-Jacob, Brice
Tran-Dinh, Alexy
Zappella, Nathalie
Snauwaert, Aurelie
Robert, Tiphaine
Rondeau, Philippe
Lagrange-Xelot, Marie
Montravers, Philippe
Couret, David
Tanaka, Sébastien
Meilhac, Olivier
author_facet Begue, Floran
Chemello, Kévin
Veeren, Bryan
Lortat-Jacob, Brice
Tran-Dinh, Alexy
Zappella, Nathalie
Snauwaert, Aurelie
Robert, Tiphaine
Rondeau, Philippe
Lagrange-Xelot, Marie
Montravers, Philippe
Couret, David
Tanaka, Sébastien
Meilhac, Olivier
author_sort Begue, Floran
collection PubMed
description SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of apolipoprotein levels during COVID-19 is not well described and understood. The objective of our study is to measure plasma levels of 14 apolipoproteins in patients with COVID-19 and to evaluate the relationships between apolipoprotein levels, severity factors and patient outcomes. From November to March 2021, 44 patients were recruited on admission to the intensive care unit because of COVID-19. Fourteen apolipoproteins and LCAT were measured by LC-MS/MS in plasma of 44 COVID-19 patients on admission to the ICU and 44 healthy control subjects. Absolute apolipoprotein concentrations were compared between COVID-19 patients and controls. Plasma apolipoproteins (Apo) A (I, II, IV), C(I, II), D, H, J and M and LCAT were lower in COVID-19 patients, whereas Apo E was higher. COVID-19 severity factors such as PaO2/FiO2 ratio, SO-FA score and CRP were correlated with certain apolipoproteins. Lower Apo B100 and LCAT levels were observed in non-survivors of COVID-19 versus survivors. To conclude, in this study, lipid and apolipoprotein profiles are altered in COVID-19 patients. Low Apo B100 and LCAT levels may be predictive of non-survival in COVID-19 patients.
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spelling pubmed-100034292023-03-11 Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study Begue, Floran Chemello, Kévin Veeren, Bryan Lortat-Jacob, Brice Tran-Dinh, Alexy Zappella, Nathalie Snauwaert, Aurelie Robert, Tiphaine Rondeau, Philippe Lagrange-Xelot, Marie Montravers, Philippe Couret, David Tanaka, Sébastien Meilhac, Olivier Int J Mol Sci Article SARS-CoV-2 infection goes beyond acute pneumonia, as it also impacts lipid metabolism. Decreased HDL-C and LDL-C levels have been reported in patients with COVID-19. The lipid profile is a less robust biochemical marker than apolipoproteins, components of lipoproteins. However, the association of apolipoprotein levels during COVID-19 is not well described and understood. The objective of our study is to measure plasma levels of 14 apolipoproteins in patients with COVID-19 and to evaluate the relationships between apolipoprotein levels, severity factors and patient outcomes. From November to March 2021, 44 patients were recruited on admission to the intensive care unit because of COVID-19. Fourteen apolipoproteins and LCAT were measured by LC-MS/MS in plasma of 44 COVID-19 patients on admission to the ICU and 44 healthy control subjects. Absolute apolipoprotein concentrations were compared between COVID-19 patients and controls. Plasma apolipoproteins (Apo) A (I, II, IV), C(I, II), D, H, J and M and LCAT were lower in COVID-19 patients, whereas Apo E was higher. COVID-19 severity factors such as PaO2/FiO2 ratio, SO-FA score and CRP were correlated with certain apolipoproteins. Lower Apo B100 and LCAT levels were observed in non-survivors of COVID-19 versus survivors. To conclude, in this study, lipid and apolipoprotein profiles are altered in COVID-19 patients. Low Apo B100 and LCAT levels may be predictive of non-survival in COVID-19 patients. MDPI 2023-02-27 /pmc/articles/PMC10003429/ /pubmed/36902035 http://dx.doi.org/10.3390/ijms24054605 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Begue, Floran
Chemello, Kévin
Veeren, Bryan
Lortat-Jacob, Brice
Tran-Dinh, Alexy
Zappella, Nathalie
Snauwaert, Aurelie
Robert, Tiphaine
Rondeau, Philippe
Lagrange-Xelot, Marie
Montravers, Philippe
Couret, David
Tanaka, Sébastien
Meilhac, Olivier
Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
title Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
title_full Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
title_fullStr Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
title_full_unstemmed Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
title_short Plasma Apolipoprotein Concentrations Are Highly Altered in Severe Intensive Care Unit COVID-19 Patients: Preliminary Results from the LIPICOR Cohort Study
title_sort plasma apolipoprotein concentrations are highly altered in severe intensive care unit covid-19 patients: preliminary results from the lipicor cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003429/
https://www.ncbi.nlm.nih.gov/pubmed/36902035
http://dx.doi.org/10.3390/ijms24054605
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