Cargando…

β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding

β-adrenoreceptors (ARs) are members of the superfamily of G-protein-coupled receptors (GPCRs), and are activated by catecholamines, such as epinephrine and norepinephrine. Three subtypes of β-ARs (β(1), β(2), and β(3)) have been identified with different distributions among ocular tissues. Important...

Descripción completa

Detalles Bibliográficos
Autores principales: Böhm, Elsa Wilma, Stoffelns, Bernhard, Gericke, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003534/
https://www.ncbi.nlm.nih.gov/pubmed/36902129
http://dx.doi.org/10.3390/ijms24054698
_version_ 1784904625115103232
author Böhm, Elsa Wilma
Stoffelns, Bernhard
Gericke, Adrian
author_facet Böhm, Elsa Wilma
Stoffelns, Bernhard
Gericke, Adrian
author_sort Böhm, Elsa Wilma
collection PubMed
description β-adrenoreceptors (ARs) are members of the superfamily of G-protein-coupled receptors (GPCRs), and are activated by catecholamines, such as epinephrine and norepinephrine. Three subtypes of β-ARs (β(1), β(2), and β(3)) have been identified with different distributions among ocular tissues. Importantly, β-ARs are an established target in the treatment of glaucoma. Moreover, β-adrenergic signaling has been associated with the development and progression of various tumor types. Hence, β-ARs are a potential therapeutic target for ocular neoplasms, such as ocular hemangioma and uveal melanoma. This review aims to discuss the expression and function of individual β-AR subtypes in ocular structures, as well as their role in the treatment of ocular diseases, including ocular tumors.
format Online
Article
Text
id pubmed-10003534
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100035342023-03-11 β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding Böhm, Elsa Wilma Stoffelns, Bernhard Gericke, Adrian Int J Mol Sci Review β-adrenoreceptors (ARs) are members of the superfamily of G-protein-coupled receptors (GPCRs), and are activated by catecholamines, such as epinephrine and norepinephrine. Three subtypes of β-ARs (β(1), β(2), and β(3)) have been identified with different distributions among ocular tissues. Importantly, β-ARs are an established target in the treatment of glaucoma. Moreover, β-adrenergic signaling has been associated with the development and progression of various tumor types. Hence, β-ARs are a potential therapeutic target for ocular neoplasms, such as ocular hemangioma and uveal melanoma. This review aims to discuss the expression and function of individual β-AR subtypes in ocular structures, as well as their role in the treatment of ocular diseases, including ocular tumors. MDPI 2023-02-28 /pmc/articles/PMC10003534/ /pubmed/36902129 http://dx.doi.org/10.3390/ijms24054698 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Böhm, Elsa Wilma
Stoffelns, Bernhard
Gericke, Adrian
β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
title β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
title_full β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
title_fullStr β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
title_full_unstemmed β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
title_short β-Adrenoreceptors as Therapeutic Targets for Ocular Tumors and Other Eye Diseases—Historical Aspects and Nowadays Understanding
title_sort β-adrenoreceptors as therapeutic targets for ocular tumors and other eye diseases—historical aspects and nowadays understanding
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003534/
https://www.ncbi.nlm.nih.gov/pubmed/36902129
http://dx.doi.org/10.3390/ijms24054698
work_keys_str_mv AT bohmelsawilma badrenoreceptorsastherapeutictargetsforoculartumorsandothereyediseaseshistoricalaspectsandnowadaysunderstanding
AT stoffelnsbernhard badrenoreceptorsastherapeutictargetsforoculartumorsandothereyediseaseshistoricalaspectsandnowadaysunderstanding
AT gerickeadrian badrenoreceptorsastherapeutictargetsforoculartumorsandothereyediseaseshistoricalaspectsandnowadaysunderstanding