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Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma

Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiom...

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Autores principales: Lan, Tien-Li, Lin, Chun-Fu, Lee, Yi-Yen, Lin, Ko-Han, Chang, Feng-Chi, Lin, Shih-Chieh, Lee, Jia-Cheng, Chou, Fong-In, Peir, Jinn-Jer, Liu, Hong-Ming, Mu, Pei-Fan, Chen, Yi-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003570/
https://www.ncbi.nlm.nih.gov/pubmed/36902408
http://dx.doi.org/10.3390/ijms24054978
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author Lan, Tien-Li
Lin, Chun-Fu
Lee, Yi-Yen
Lin, Ko-Han
Chang, Feng-Chi
Lin, Shih-Chieh
Lee, Jia-Cheng
Chou, Fong-In
Peir, Jinn-Jer
Liu, Hong-Ming
Mu, Pei-Fan
Chen, Yi-Wei
author_facet Lan, Tien-Li
Lin, Chun-Fu
Lee, Yi-Yen
Lin, Ko-Han
Chang, Feng-Chi
Lin, Shih-Chieh
Lee, Jia-Cheng
Chou, Fong-In
Peir, Jinn-Jer
Liu, Hong-Ming
Mu, Pei-Fan
Chen, Yi-Wei
author_sort Lan, Tien-Li
collection PubMed
description Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas.
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spelling pubmed-100035702023-03-11 Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma Lan, Tien-Li Lin, Chun-Fu Lee, Yi-Yen Lin, Ko-Han Chang, Feng-Chi Lin, Shih-Chieh Lee, Jia-Cheng Chou, Fong-In Peir, Jinn-Jer Liu, Hong-Ming Mu, Pei-Fan Chen, Yi-Wei Int J Mol Sci Article Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas. MDPI 2023-03-04 /pmc/articles/PMC10003570/ /pubmed/36902408 http://dx.doi.org/10.3390/ijms24054978 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lan, Tien-Li
Lin, Chun-Fu
Lee, Yi-Yen
Lin, Ko-Han
Chang, Feng-Chi
Lin, Shih-Chieh
Lee, Jia-Cheng
Chou, Fong-In
Peir, Jinn-Jer
Liu, Hong-Ming
Mu, Pei-Fan
Chen, Yi-Wei
Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
title Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
title_full Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
title_fullStr Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
title_full_unstemmed Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
title_short Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
title_sort advances in boron neutron capture therapy (bnct) for recurrent intracranial meningioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003570/
https://www.ncbi.nlm.nih.gov/pubmed/36902408
http://dx.doi.org/10.3390/ijms24054978
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