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Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma
Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiom...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003570/ https://www.ncbi.nlm.nih.gov/pubmed/36902408 http://dx.doi.org/10.3390/ijms24054978 |
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author | Lan, Tien-Li Lin, Chun-Fu Lee, Yi-Yen Lin, Ko-Han Chang, Feng-Chi Lin, Shih-Chieh Lee, Jia-Cheng Chou, Fong-In Peir, Jinn-Jer Liu, Hong-Ming Mu, Pei-Fan Chen, Yi-Wei |
author_facet | Lan, Tien-Li Lin, Chun-Fu Lee, Yi-Yen Lin, Ko-Han Chang, Feng-Chi Lin, Shih-Chieh Lee, Jia-Cheng Chou, Fong-In Peir, Jinn-Jer Liu, Hong-Ming Mu, Pei-Fan Chen, Yi-Wei |
author_sort | Lan, Tien-Li |
collection | PubMed |
description | Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas. |
format | Online Article Text |
id | pubmed-10003570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100035702023-03-11 Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma Lan, Tien-Li Lin, Chun-Fu Lee, Yi-Yen Lin, Ko-Han Chang, Feng-Chi Lin, Shih-Chieh Lee, Jia-Cheng Chou, Fong-In Peir, Jinn-Jer Liu, Hong-Ming Mu, Pei-Fan Chen, Yi-Wei Int J Mol Sci Article Meningiomas are the most frequently diagnosed primary intracranial tumors in adults. Surgical resection is preferred if the meningioma is accessible; for those that are not suitable for surgical resection, radiotherapy should be considered to improve local tumor control. However, recurrent meningiomas are challenging to treat, as the recurrent tumor might be located in the previously irradiated area. Boron Neutron Capture Therapy (BNCT) is a highly selective radiotherapy modality in which the cytotoxic effect focuses mainly on cells with increased uptake of boron-containing drugs. In this article, we describe four patients with recurrent meningiomas treated with BNCT in Taiwan. The mean boron-containing drug tumor-to-normal tissue uptake ratio was 4.125, and the tumor mean dose was 29.414 GyE, received via BNCT. The treatment response showed two stable diseases, one partial response, and one complete response. We also introduce and support the effectiveness and safety of BNCT as an alternative salvage treatment for recurrent meningiomas. MDPI 2023-03-04 /pmc/articles/PMC10003570/ /pubmed/36902408 http://dx.doi.org/10.3390/ijms24054978 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lan, Tien-Li Lin, Chun-Fu Lee, Yi-Yen Lin, Ko-Han Chang, Feng-Chi Lin, Shih-Chieh Lee, Jia-Cheng Chou, Fong-In Peir, Jinn-Jer Liu, Hong-Ming Mu, Pei-Fan Chen, Yi-Wei Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
title | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
title_full | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
title_fullStr | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
title_full_unstemmed | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
title_short | Advances in Boron Neutron Capture Therapy (BNCT) for Recurrent Intracranial Meningioma |
title_sort | advances in boron neutron capture therapy (bnct) for recurrent intracranial meningioma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003570/ https://www.ncbi.nlm.nih.gov/pubmed/36902408 http://dx.doi.org/10.3390/ijms24054978 |
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