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Strategies for participant retention in long term clinical trials: A participant –centric approaches

A clinical trial is the most foolproof method to evaluate the efficacy of a new intervention. Successful completion of clinical trials depends on the retention of the participants enrolled. Poor participant retention can lead to significant time and cost burden and have potentially adverse biases on...

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Autores principales: Poongothai, Subramani, Anjana, Ranjit Mohan, Aarthy, Ramasamy, Unnikrishnan, Ranjit, Venkat Narayan, K. M., Ali, Mohammed K., Karkuzhali, Kulasegaran, Mohan, Viswanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003583/
https://www.ncbi.nlm.nih.gov/pubmed/36909219
http://dx.doi.org/10.4103/picr.picr_161_21
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author Poongothai, Subramani
Anjana, Ranjit Mohan
Aarthy, Ramasamy
Unnikrishnan, Ranjit
Venkat Narayan, K. M.
Ali, Mohammed K.
Karkuzhali, Kulasegaran
Mohan, Viswanathan
author_facet Poongothai, Subramani
Anjana, Ranjit Mohan
Aarthy, Ramasamy
Unnikrishnan, Ranjit
Venkat Narayan, K. M.
Ali, Mohammed K.
Karkuzhali, Kulasegaran
Mohan, Viswanathan
author_sort Poongothai, Subramani
collection PubMed
description A clinical trial is the most foolproof method to evaluate the efficacy of a new intervention. Successful completion of clinical trials depends on the retention of the participants enrolled. Poor participant retention can lead to significant time and cost burden and have potentially adverse biases on the results. A high retention rate of participants is an important criterion for the validity and credibility of randomized controlled clinical trials. Many long-term trials fail due to low retention of study participants. Efforts at participant retention should start even before the first participant is recruited into the study. Retention is not only the responsibility of the investigators but also all other stakeholders in a clinical trial. In recent years, retention materials, participant camps, and introduction of national study coordinators have helped in improving retention. Quality of the relationship developed between the research staff and the study participant is a key factor for success of any trial. In our experience, in the context of resource-challenged low- and middle-income countries, we have found that it is possible to achieve high retention rates, 95%–100%. The rapport built between the investigating team and the participant plays a vital role in retention. In addition, personalized care, including listening to the participant's problems and enabling to contact investigators or study team at any time of the day, has shown benefits in retention.
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spelling pubmed-100035832023-03-11 Strategies for participant retention in long term clinical trials: A participant –centric approaches Poongothai, Subramani Anjana, Ranjit Mohan Aarthy, Ramasamy Unnikrishnan, Ranjit Venkat Narayan, K. M. Ali, Mohammed K. Karkuzhali, Kulasegaran Mohan, Viswanathan Perspect Clin Res Review Article A clinical trial is the most foolproof method to evaluate the efficacy of a new intervention. Successful completion of clinical trials depends on the retention of the participants enrolled. Poor participant retention can lead to significant time and cost burden and have potentially adverse biases on the results. A high retention rate of participants is an important criterion for the validity and credibility of randomized controlled clinical trials. Many long-term trials fail due to low retention of study participants. Efforts at participant retention should start even before the first participant is recruited into the study. Retention is not only the responsibility of the investigators but also all other stakeholders in a clinical trial. In recent years, retention materials, participant camps, and introduction of national study coordinators have helped in improving retention. Quality of the relationship developed between the research staff and the study participant is a key factor for success of any trial. In our experience, in the context of resource-challenged low- and middle-income countries, we have found that it is possible to achieve high retention rates, 95%–100%. The rapport built between the investigating team and the participant plays a vital role in retention. In addition, personalized care, including listening to the participant's problems and enabling to contact investigators or study team at any time of the day, has shown benefits in retention. Wolters Kluwer - Medknow 2023 2022-07-23 /pmc/articles/PMC10003583/ /pubmed/36909219 http://dx.doi.org/10.4103/picr.picr_161_21 Text en Copyright: © 2022 Perspectives in Clinical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Poongothai, Subramani
Anjana, Ranjit Mohan
Aarthy, Ramasamy
Unnikrishnan, Ranjit
Venkat Narayan, K. M.
Ali, Mohammed K.
Karkuzhali, Kulasegaran
Mohan, Viswanathan
Strategies for participant retention in long term clinical trials: A participant –centric approaches
title Strategies for participant retention in long term clinical trials: A participant –centric approaches
title_full Strategies for participant retention in long term clinical trials: A participant –centric approaches
title_fullStr Strategies for participant retention in long term clinical trials: A participant –centric approaches
title_full_unstemmed Strategies for participant retention in long term clinical trials: A participant –centric approaches
title_short Strategies for participant retention in long term clinical trials: A participant –centric approaches
title_sort strategies for participant retention in long term clinical trials: a participant –centric approaches
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003583/
https://www.ncbi.nlm.nih.gov/pubmed/36909219
http://dx.doi.org/10.4103/picr.picr_161_21
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