Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis

Over the last several years, the use of biomarkers in the diagnosis of patients with heart failure (HF) has skyrocketed. Natriuretic peptides are currently the most widely used biomarker in the diagnosis and prognosis of individuals with HF. Proenkephalin (PENK) activates delta-opioid receptors in c...

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Autores principales: Siranart, Noppachai, Laohasurayotin, Khamik, Phanthong, Tanattida, Sowalertrat, Walit, Ariyachaipanich, Aekarach, Chokesuwattanaskul, Ronpichai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003589/
https://www.ncbi.nlm.nih.gov/pubmed/36902318
http://dx.doi.org/10.3390/ijms24054887
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author Siranart, Noppachai
Laohasurayotin, Khamik
Phanthong, Tanattida
Sowalertrat, Walit
Ariyachaipanich, Aekarach
Chokesuwattanaskul, Ronpichai
author_facet Siranart, Noppachai
Laohasurayotin, Khamik
Phanthong, Tanattida
Sowalertrat, Walit
Ariyachaipanich, Aekarach
Chokesuwattanaskul, Ronpichai
author_sort Siranart, Noppachai
collection PubMed
description Over the last several years, the use of biomarkers in the diagnosis of patients with heart failure (HF) has skyrocketed. Natriuretic peptides are currently the most widely used biomarker in the diagnosis and prognosis of individuals with HF. Proenkephalin (PENK) activates delta-opioid receptors in cardiac tissue, resulting in a decreased myocardial contractility and heart rate. However, the goal of this meta-analysis is to evaluate the association between the PENK level at the time of admission and prognosis in patients with HF, such as all-cause mortality, rehospitalization, and decreasing renal function. High PENK levels have been associated with a worsened prognosis in patients with HF.
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spelling pubmed-100035892023-03-11 Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis Siranart, Noppachai Laohasurayotin, Khamik Phanthong, Tanattida Sowalertrat, Walit Ariyachaipanich, Aekarach Chokesuwattanaskul, Ronpichai Int J Mol Sci Review Over the last several years, the use of biomarkers in the diagnosis of patients with heart failure (HF) has skyrocketed. Natriuretic peptides are currently the most widely used biomarker in the diagnosis and prognosis of individuals with HF. Proenkephalin (PENK) activates delta-opioid receptors in cardiac tissue, resulting in a decreased myocardial contractility and heart rate. However, the goal of this meta-analysis is to evaluate the association between the PENK level at the time of admission and prognosis in patients with HF, such as all-cause mortality, rehospitalization, and decreasing renal function. High PENK levels have been associated with a worsened prognosis in patients with HF. MDPI 2023-03-03 /pmc/articles/PMC10003589/ /pubmed/36902318 http://dx.doi.org/10.3390/ijms24054887 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Siranart, Noppachai
Laohasurayotin, Khamik
Phanthong, Tanattida
Sowalertrat, Walit
Ariyachaipanich, Aekarach
Chokesuwattanaskul, Ronpichai
Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis
title Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis
title_full Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis
title_fullStr Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis
title_full_unstemmed Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis
title_short Proenkephalin as a Novel Prognostic Marker in Heart Failure Patients: A Systematic Review and Meta-Analysis
title_sort proenkephalin as a novel prognostic marker in heart failure patients: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003589/
https://www.ncbi.nlm.nih.gov/pubmed/36902318
http://dx.doi.org/10.3390/ijms24054887
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