LPS Triggers Acute Neuroinflammation and Parkinsonism Involving NLRP3 Inflammasome Pathway and Mitochondrial CI Dysfunction in the Rat

Whether neuroinflammation leads to dopaminergic nigrostriatal system neurodegeneration is controversial. We addressed this issue by inducing acute neuroinflammation in the substantia nigra (SN) with a single local administration (5 µg/2 µL saline solution) of lipopolysaccharide (LPS). Neuroinflammat...

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Detalles Bibliográficos
Autores principales: Valenzuela-Arzeta, Irais E., Soto-Rojas, Luis O., Flores-Martinez, Yazmin M., Delgado-Minjares, Karen M., Gatica-Garcia, Bismark, Mascotte-Cruz, Juan U., Nava, Porfirio, Aparicio-Trejo, Omar Emiliano, Reyes-Corona, David, Martínez-Dávila, Irma A., Gutierrez-Castillo, M. E., Espadas-Alvarez, Armando J., Orozco-Barrios, Carlos E., Martinez-Fong, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003606/
https://www.ncbi.nlm.nih.gov/pubmed/36902058
http://dx.doi.org/10.3390/ijms24054628

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