Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma

Chitotriosidase (CHIT1) is an enzyme produced by macrophages that regulates their differentiation and polarization. Lung macrophages have been implicated in asthma development; therefore, we asked whether pharmacological inhibition of macrophage-specific CHIT1 would have beneficial effects in asthma...

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Detalles Bibliográficos
Autores principales: Sklepkiewicz, Piotr, Dymek, Barbara, Mlacki, Michal, Zagozdzon, Agnieszka, Salamon, Magdalena, Siwińska, Anna Maria, Mazurkiewicz, Marcin Piotr, de Souza Xavier Costa, Natalia, Mazur, Marzena, Mauad, Thais, Gołębiowski, Adam, Dzwonek, Karolina, Gołąb, Jakub, Zasłona, Zbigniew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003607/
https://www.ncbi.nlm.nih.gov/pubmed/36902148
http://dx.doi.org/10.3390/ijms24054719

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