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Zinc: From Biological Functions to Therapeutic Potential
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription fa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003636/ https://www.ncbi.nlm.nih.gov/pubmed/36902254 http://dx.doi.org/10.3390/ijms24054822 |
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author | Costa, Maria Inês Sarmento-Ribeiro, Ana Bela Gonçalves, Ana Cristina |
author_facet | Costa, Maria Inês Sarmento-Ribeiro, Ana Bela Gonçalves, Ana Cristina |
author_sort | Costa, Maria Inês |
collection | PubMed |
description | The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson’s disease, Alzheimer’s disease, and other age-related diseases. This review focuses on Zn’s roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases. |
format | Online Article Text |
id | pubmed-10003636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100036362023-03-11 Zinc: From Biological Functions to Therapeutic Potential Costa, Maria Inês Sarmento-Ribeiro, Ana Bela Gonçalves, Ana Cristina Int J Mol Sci Review The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson’s disease, Alzheimer’s disease, and other age-related diseases. This review focuses on Zn’s roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases. MDPI 2023-03-02 /pmc/articles/PMC10003636/ /pubmed/36902254 http://dx.doi.org/10.3390/ijms24054822 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Costa, Maria Inês Sarmento-Ribeiro, Ana Bela Gonçalves, Ana Cristina Zinc: From Biological Functions to Therapeutic Potential |
title | Zinc: From Biological Functions to Therapeutic Potential |
title_full | Zinc: From Biological Functions to Therapeutic Potential |
title_fullStr | Zinc: From Biological Functions to Therapeutic Potential |
title_full_unstemmed | Zinc: From Biological Functions to Therapeutic Potential |
title_short | Zinc: From Biological Functions to Therapeutic Potential |
title_sort | zinc: from biological functions to therapeutic potential |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003636/ https://www.ncbi.nlm.nih.gov/pubmed/36902254 http://dx.doi.org/10.3390/ijms24054822 |
work_keys_str_mv | AT costamariaines zincfrombiologicalfunctionstotherapeuticpotential AT sarmentoribeiroanabela zincfrombiologicalfunctionstotherapeuticpotential AT goncalvesanacristina zincfrombiologicalfunctionstotherapeuticpotential |