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Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action
Low-color-temperature light-emitting diodes (LEDs) (called 1900 K LEDs for short) have the potential to become a healthy light source due to their blue-free property. Our previous research demonstrated that these LEDs posed no harm to retinal cells and even protected the ocular surface. Treatment ta...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003667/ https://www.ncbi.nlm.nih.gov/pubmed/36902225 http://dx.doi.org/10.3390/ijms24054794 |
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author | Jin, Ming Zhang, Xiao-Yu Ying, Qian Hu, Hai-Jian Feng, Xin-Ting Peng, Zhen Pang, Yu-Lian Yan, Feng Zhang, Xu |
author_facet | Jin, Ming Zhang, Xiao-Yu Ying, Qian Hu, Hai-Jian Feng, Xin-Ting Peng, Zhen Pang, Yu-Lian Yan, Feng Zhang, Xu |
author_sort | Jin, Ming |
collection | PubMed |
description | Low-color-temperature light-emitting diodes (LEDs) (called 1900 K LEDs for short) have the potential to become a healthy light source due to their blue-free property. Our previous research demonstrated that these LEDs posed no harm to retinal cells and even protected the ocular surface. Treatment targeting the retinal pigment epithelium (RPE) is a promising direction for age-related macular degeneration (AMD). Nevertheless, no study has evaluated the protective effects of these LEDs on RPE. Therefore, we used the ARPE-19 cell line and zebrafish to explore the protective effects of 1900 K LEDs. Our results showed that the 1900 K LEDs could increase the cell vitality of ARPE-19 cells at different irradiances, with the most pronounced effect at 10 W/m(2). Moreover, the protective effect increased with time. Pretreatment with 1900 K LEDs could protect the RPE from death after hydrogen peroxide (H(2)O(2)) damage by reducing reactive oxygen species (ROS) generation and mitochondrial damage caused by H(2)O(2). In addition, we preliminarily demonstrated that irradiation with 1900 K LEDs in zebrafish did not cause retinal damage. To sum up, we provide evidence for the protective effects of 1900 K LEDs on the RPE, laying the foundation for future light therapy using these LEDs. |
format | Online Article Text |
id | pubmed-10003667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100036672023-03-11 Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action Jin, Ming Zhang, Xiao-Yu Ying, Qian Hu, Hai-Jian Feng, Xin-Ting Peng, Zhen Pang, Yu-Lian Yan, Feng Zhang, Xu Int J Mol Sci Article Low-color-temperature light-emitting diodes (LEDs) (called 1900 K LEDs for short) have the potential to become a healthy light source due to their blue-free property. Our previous research demonstrated that these LEDs posed no harm to retinal cells and even protected the ocular surface. Treatment targeting the retinal pigment epithelium (RPE) is a promising direction for age-related macular degeneration (AMD). Nevertheless, no study has evaluated the protective effects of these LEDs on RPE. Therefore, we used the ARPE-19 cell line and zebrafish to explore the protective effects of 1900 K LEDs. Our results showed that the 1900 K LEDs could increase the cell vitality of ARPE-19 cells at different irradiances, with the most pronounced effect at 10 W/m(2). Moreover, the protective effect increased with time. Pretreatment with 1900 K LEDs could protect the RPE from death after hydrogen peroxide (H(2)O(2)) damage by reducing reactive oxygen species (ROS) generation and mitochondrial damage caused by H(2)O(2). In addition, we preliminarily demonstrated that irradiation with 1900 K LEDs in zebrafish did not cause retinal damage. To sum up, we provide evidence for the protective effects of 1900 K LEDs on the RPE, laying the foundation for future light therapy using these LEDs. MDPI 2023-03-01 /pmc/articles/PMC10003667/ /pubmed/36902225 http://dx.doi.org/10.3390/ijms24054794 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jin, Ming Zhang, Xiao-Yu Ying, Qian Hu, Hai-Jian Feng, Xin-Ting Peng, Zhen Pang, Yu-Lian Yan, Feng Zhang, Xu Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action |
title | Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action |
title_full | Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action |
title_fullStr | Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action |
title_full_unstemmed | Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action |
title_short | Antioxidative and Mitochondrial Protection in Retinal Pigment Epithelium: New Light Source in Action |
title_sort | antioxidative and mitochondrial protection in retinal pigment epithelium: new light source in action |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003667/ https://www.ncbi.nlm.nih.gov/pubmed/36902225 http://dx.doi.org/10.3390/ijms24054794 |
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