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Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation
Background: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are enterococci (EC-IE) and staphylococci (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC-IE and SC-IE. Methods: TAVI-IE patien...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003722/ https://www.ncbi.nlm.nih.gov/pubmed/36902604 http://dx.doi.org/10.3390/jcm12051817 |
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author | Gasior, Tomasz Woitek, Felix J. Schroth, Antonia Abdel-Wahab, Mohamed Crusius, Lisa Haussig, Stephan Kiefer, Philipp Scislo, Piotr Huczek, Zenon Dabrowski, Maciej Witkowski, Adam Olasinska-Wisniewska, Anna Grygier, Marek Protasiewicz, Marcin Hudziak, Damian Kappert, Utz Holzhey, David Wojakowski, Wojtek Linke, Axel Mangner, Norman |
author_facet | Gasior, Tomasz Woitek, Felix J. Schroth, Antonia Abdel-Wahab, Mohamed Crusius, Lisa Haussig, Stephan Kiefer, Philipp Scislo, Piotr Huczek, Zenon Dabrowski, Maciej Witkowski, Adam Olasinska-Wisniewska, Anna Grygier, Marek Protasiewicz, Marcin Hudziak, Damian Kappert, Utz Holzhey, David Wojakowski, Wojtek Linke, Axel Mangner, Norman |
author_sort | Gasior, Tomasz |
collection | PubMed |
description | Background: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are enterococci (EC-IE) and staphylococci (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC-IE and SC-IE. Methods: TAVI-IE patients from 2007 to 2021 were included in this analysis. The 1-year mortality was the primary outcome measure of this retrospective multi-center analysis. Results: Out of 163 patients, 53 (32.5%) EC-IE and 69 (42.3%) SC-IE patients were included. Subjects were comparable with regard to age, sex, and clinically relevant baseline comorbidities. Symptoms at admission were not significantly different between groups, except for a lower risk for presenting with septic shock in EC-IE than SC-IE. Treatment was performed in 78% by antibiotics alone and in 22% of patients by surgery and antibiotics, with no significant differences between groups. The rate of any complication, in particular heart failure, renal failure, and septic shock during treatment for IE, was lower in EC-IE compared with SC-IE (p < 0.05). In-hospital (EC-IE: 36% vs. SC-IE: 56%, p = 0.035) and 1-year mortality (EC-IE: 51% vs. SC-IE: 70%, p = 0.009) were significantly lower in EC-IE compared with SC-IE. Conclusions: EC-IE, compared with SC-IE, was associated with a lower morbidity and mortality. However, absolute numbers are high, a finding that should trigger further research in appropriate perioperative antibiotic management and improvement of early IE diagnosis in the case of clinical suspicion. |
format | Online Article Text |
id | pubmed-10003722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100037222023-03-11 Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation Gasior, Tomasz Woitek, Felix J. Schroth, Antonia Abdel-Wahab, Mohamed Crusius, Lisa Haussig, Stephan Kiefer, Philipp Scislo, Piotr Huczek, Zenon Dabrowski, Maciej Witkowski, Adam Olasinska-Wisniewska, Anna Grygier, Marek Protasiewicz, Marcin Hudziak, Damian Kappert, Utz Holzhey, David Wojakowski, Wojtek Linke, Axel Mangner, Norman J Clin Med Article Background: The two most common organisms found in infective endocarditis following transcatheter aortic valve implantation (TAVI-IE) are enterococci (EC-IE) and staphylococci (SC-IE). We aimed to compare clinical characteristics and outcomes of patients with EC-IE and SC-IE. Methods: TAVI-IE patients from 2007 to 2021 were included in this analysis. The 1-year mortality was the primary outcome measure of this retrospective multi-center analysis. Results: Out of 163 patients, 53 (32.5%) EC-IE and 69 (42.3%) SC-IE patients were included. Subjects were comparable with regard to age, sex, and clinically relevant baseline comorbidities. Symptoms at admission were not significantly different between groups, except for a lower risk for presenting with septic shock in EC-IE than SC-IE. Treatment was performed in 78% by antibiotics alone and in 22% of patients by surgery and antibiotics, with no significant differences between groups. The rate of any complication, in particular heart failure, renal failure, and septic shock during treatment for IE, was lower in EC-IE compared with SC-IE (p < 0.05). In-hospital (EC-IE: 36% vs. SC-IE: 56%, p = 0.035) and 1-year mortality (EC-IE: 51% vs. SC-IE: 70%, p = 0.009) were significantly lower in EC-IE compared with SC-IE. Conclusions: EC-IE, compared with SC-IE, was associated with a lower morbidity and mortality. However, absolute numbers are high, a finding that should trigger further research in appropriate perioperative antibiotic management and improvement of early IE diagnosis in the case of clinical suspicion. MDPI 2023-02-24 /pmc/articles/PMC10003722/ /pubmed/36902604 http://dx.doi.org/10.3390/jcm12051817 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gasior, Tomasz Woitek, Felix J. Schroth, Antonia Abdel-Wahab, Mohamed Crusius, Lisa Haussig, Stephan Kiefer, Philipp Scislo, Piotr Huczek, Zenon Dabrowski, Maciej Witkowski, Adam Olasinska-Wisniewska, Anna Grygier, Marek Protasiewicz, Marcin Hudziak, Damian Kappert, Utz Holzhey, David Wojakowski, Wojtek Linke, Axel Mangner, Norman Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
title | Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
title_full | Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
title_fullStr | Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
title_full_unstemmed | Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
title_short | Impact of Enterococci vs. Staphylococci Induced Infective Endocarditis after Transcatheter Aortic Valve Implantation |
title_sort | impact of enterococci vs. staphylococci induced infective endocarditis after transcatheter aortic valve implantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003722/ https://www.ncbi.nlm.nih.gov/pubmed/36902604 http://dx.doi.org/10.3390/jcm12051817 |
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