Properties of a Single Amino Acid Residue in the Third Transmembrane Domain Determine the Kinetics of Ambient Light-Sensitive Channelrhodopsin

Channelrhodopsins have been utilized in gene therapy to restore vision in patients with retinitis pigmentosa and their channel kinetics are an important factor to consider in such applications. We investigated the channel kinetics of ComV1 variants with different amino acid residues at the 172nd pos...

Descripción completa

Detalles Bibliográficos
Autores principales: Hatakeyama, Akito, Sugano, Eriko, Sayama, Tatsuki, Watanabe, Yoshito, Suzuki, Tomoya, Tabata, Kitako, Endo, Yuka, Sakajiri, Tetsuya, Fukuda, Tomokazu, Ozaki, Taku, Tomita, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003734/
https://www.ncbi.nlm.nih.gov/pubmed/36902480
http://dx.doi.org/10.3390/ijms24055054

Ejemplares similares

Ejemplares similares