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Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus

Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review sum...

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Detalles Bibliográficos
Autores principales: Azarova, Iuliia, Polonikov, Alexey, Klyosova, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003739/
https://www.ncbi.nlm.nih.gov/pubmed/36902173
http://dx.doi.org/10.3390/ijms24054738
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author Azarova, Iuliia
Polonikov, Alexey
Klyosova, Elena
author_facet Azarova, Iuliia
Polonikov, Alexey
Klyosova, Elena
author_sort Azarova, Iuliia
collection PubMed
description Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis.
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spelling pubmed-100037392023-03-11 Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus Azarova, Iuliia Polonikov, Alexey Klyosova, Elena Int J Mol Sci Review Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis. MDPI 2023-03-01 /pmc/articles/PMC10003739/ /pubmed/36902173 http://dx.doi.org/10.3390/ijms24054738 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Azarova, Iuliia
Polonikov, Alexey
Klyosova, Elena
Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
title Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
title_full Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
title_fullStr Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
title_full_unstemmed Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
title_short Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
title_sort molecular genetics of abnormal redox homeostasis in type 2 diabetes mellitus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003739/
https://www.ncbi.nlm.nih.gov/pubmed/36902173
http://dx.doi.org/10.3390/ijms24054738
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