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Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus
Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review sum...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003739/ https://www.ncbi.nlm.nih.gov/pubmed/36902173 http://dx.doi.org/10.3390/ijms24054738 |
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author | Azarova, Iuliia Polonikov, Alexey Klyosova, Elena |
author_facet | Azarova, Iuliia Polonikov, Alexey Klyosova, Elena |
author_sort | Azarova, Iuliia |
collection | PubMed |
description | Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis. |
format | Online Article Text |
id | pubmed-10003739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100037392023-03-11 Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus Azarova, Iuliia Polonikov, Alexey Klyosova, Elena Int J Mol Sci Review Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review summarizes the current state of the art advances in understanding the role of abnormal redox homeostasis in the molecular mechanisms of T2D and provides comprehensive information on the characteristics and biological functions of antioxidant and oxidative enzymes, as well as discusses genetic studies conducted so far in order to investigate the contribution of polymorphisms in genes encoding redox state-regulating enzymes to the disease pathogenesis. MDPI 2023-03-01 /pmc/articles/PMC10003739/ /pubmed/36902173 http://dx.doi.org/10.3390/ijms24054738 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Azarova, Iuliia Polonikov, Alexey Klyosova, Elena Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus |
title | Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus |
title_full | Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus |
title_fullStr | Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus |
title_full_unstemmed | Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus |
title_short | Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus |
title_sort | molecular genetics of abnormal redox homeostasis in type 2 diabetes mellitus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003739/ https://www.ncbi.nlm.nih.gov/pubmed/36902173 http://dx.doi.org/10.3390/ijms24054738 |
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