Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I

In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When dope...

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Autores principales: Kalbarczyk, Marta, Szcześ, Aleksandra, Belcarz, Anna, Kazimierczak, Paulina, May, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003787/
https://www.ncbi.nlm.nih.gov/pubmed/36903085
http://dx.doi.org/10.3390/ma16051971
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author Kalbarczyk, Marta
Szcześ, Aleksandra
Belcarz, Anna
Kazimierczak, Paulina
May, Zoltan
author_facet Kalbarczyk, Marta
Szcześ, Aleksandra
Belcarz, Anna
Kazimierczak, Paulina
May, Zoltan
author_sort Kalbarczyk, Marta
collection PubMed
description In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against S. aureus and E. coli. Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity.
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spelling pubmed-100037872023-03-11 Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I Kalbarczyk, Marta Szcześ, Aleksandra Belcarz, Anna Kazimierczak, Paulina May, Zoltan Materials (Basel) Article In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against S. aureus and E. coli. Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity. MDPI 2023-02-28 /pmc/articles/PMC10003787/ /pubmed/36903085 http://dx.doi.org/10.3390/ma16051971 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalbarczyk, Marta
Szcześ, Aleksandra
Belcarz, Anna
Kazimierczak, Paulina
May, Zoltan
Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I
title Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I
title_full Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I
title_fullStr Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I
title_full_unstemmed Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I
title_short Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I
title_sort zn-doped mono- and biphasic calcium phosphate materials derived from agriculture waste and their potential biomedical applications: part i
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003787/
https://www.ncbi.nlm.nih.gov/pubmed/36903085
http://dx.doi.org/10.3390/ma16051971
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