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Graft Failure after Uterus Transplantation in 16 Recipients: A Review
Uterus transplantation (UTx) is now an alternative to surrogacy and adoption for women with uterine factor infertility to have children; however, there are still unresolved clinical and technical issues. One of these is that the graft failure rate after transplantation is somewhat higher than that o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003853/ https://www.ncbi.nlm.nih.gov/pubmed/36902818 http://dx.doi.org/10.3390/jcm12052032 |
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author | Kisu, Iori Matsuda, Risa Shiraishi, Tetsuro Hayashi, Ryoma Matoba, Yusuke Tamate, Masato Banno, Kouji |
author_facet | Kisu, Iori Matsuda, Risa Shiraishi, Tetsuro Hayashi, Ryoma Matoba, Yusuke Tamate, Masato Banno, Kouji |
author_sort | Kisu, Iori |
collection | PubMed |
description | Uterus transplantation (UTx) is now an alternative to surrogacy and adoption for women with uterine factor infertility to have children; however, there are still unresolved clinical and technical issues. One of these is that the graft failure rate after transplantation is somewhat higher than that of other life-saving organ transplants, which is a critical concern. Herein, we summarize the details of 16 graft failures after UTx with living or deceased donors using the published literature in order to learn from these negative outcomes. To date, the main causes of graft failure are vascular factors (arterial and/or venous thrombosis, atherosclerosis, and poor perfusion). Many recipients with thrombosis develop graft failure within one month of surgery. Therefore, it is necessary to devise a safe and stable surgical technique with higher success rates for further development in the UTx field. |
format | Online Article Text |
id | pubmed-10003853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100038532023-03-11 Graft Failure after Uterus Transplantation in 16 Recipients: A Review Kisu, Iori Matsuda, Risa Shiraishi, Tetsuro Hayashi, Ryoma Matoba, Yusuke Tamate, Masato Banno, Kouji J Clin Med Review Uterus transplantation (UTx) is now an alternative to surrogacy and adoption for women with uterine factor infertility to have children; however, there are still unresolved clinical and technical issues. One of these is that the graft failure rate after transplantation is somewhat higher than that of other life-saving organ transplants, which is a critical concern. Herein, we summarize the details of 16 graft failures after UTx with living or deceased donors using the published literature in order to learn from these negative outcomes. To date, the main causes of graft failure are vascular factors (arterial and/or venous thrombosis, atherosclerosis, and poor perfusion). Many recipients with thrombosis develop graft failure within one month of surgery. Therefore, it is necessary to devise a safe and stable surgical technique with higher success rates for further development in the UTx field. MDPI 2023-03-03 /pmc/articles/PMC10003853/ /pubmed/36902818 http://dx.doi.org/10.3390/jcm12052032 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kisu, Iori Matsuda, Risa Shiraishi, Tetsuro Hayashi, Ryoma Matoba, Yusuke Tamate, Masato Banno, Kouji Graft Failure after Uterus Transplantation in 16 Recipients: A Review |
title | Graft Failure after Uterus Transplantation in 16 Recipients: A Review |
title_full | Graft Failure after Uterus Transplantation in 16 Recipients: A Review |
title_fullStr | Graft Failure after Uterus Transplantation in 16 Recipients: A Review |
title_full_unstemmed | Graft Failure after Uterus Transplantation in 16 Recipients: A Review |
title_short | Graft Failure after Uterus Transplantation in 16 Recipients: A Review |
title_sort | graft failure after uterus transplantation in 16 recipients: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003853/ https://www.ncbi.nlm.nih.gov/pubmed/36902818 http://dx.doi.org/10.3390/jcm12052032 |
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