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Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews
Background: Growing evidence supports exercise for people with lung cancer. This overview aimed to summarise exercise intervention efficacy and safety across the care continuum. Methods: Eight databases (including Cochrane and Medline) were searched (inception—February 2022) for systematic reviews o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003899/ https://www.ncbi.nlm.nih.gov/pubmed/36902659 http://dx.doi.org/10.3390/jcm12051871 |
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author | Edbrooke, Lara Bowman, Amy Granger, Catherine L. Burgess, Nicola Abo, Shaza Connolly, Bronwen Denehy, Linda |
author_facet | Edbrooke, Lara Bowman, Amy Granger, Catherine L. Burgess, Nicola Abo, Shaza Connolly, Bronwen Denehy, Linda |
author_sort | Edbrooke, Lara |
collection | PubMed |
description | Background: Growing evidence supports exercise for people with lung cancer. This overview aimed to summarise exercise intervention efficacy and safety across the care continuum. Methods: Eight databases (including Cochrane and Medline) were searched (inception—February 2022) for systematic reviews of RCTs/quasi-RCTs. Eligibility: population—adults with lung cancer; intervention: exercise (e.g., aerobic, resistance) +/− non-exercise (e.g., nutrition); comparator: usual care/non-exercise; primary outcomes: exercise capacity, physical function, health-related quality of life (HRQoL) and post-operative complications. Duplicate, independent title/abstract and full-text screening, data extraction and quality ratings (AMSTAR-2) were completed. Results: Thirty systematic reviews involving between 157 and 2109 participants (n = 6440 total) were included. Most reviews (n = 28) involved surgical participants. Twenty-five reviews performed meta-analyses. The review quality was commonly rated critically low (n = 22) or low (n = 7). Reviews commonly included combinations of aerobic, resistance and/or respiratory exercise interventions. Pre-operative meta-analyses demonstrated that exercise reduces post-operative complications (n = 4/7) and improves exercise capacity (n = 6/6), whilst HRQoL findings were non-significant (n = 3/3). Post-operative meta-analyses reported significant improvements in exercise capacity (n = 2/3) and muscle strength (n = 1/1) and non-significant HRQoL changes (n = 8/10). Interventions delivered to mixed surgical and non-surgical populations improved exercise capacity (n = 3/4), muscle strength (n = 2/2) and HRQoL (n = 3). Meta-analyses of interventions in non-surgical populations demonstrated inconsistent findings. Adverse event rates were low, however, few reviews reported on safety. Conclusions: A large body of evidence supports lung cancer exercise interventions to reduce complications and improve exercise capacity in pre- and post-operative populations. Additional higher-quality research is needed, particularly in the non-surgical population, including subgroup analyses of exercise type and setting. |
format | Online Article Text |
id | pubmed-10003899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100038992023-03-11 Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews Edbrooke, Lara Bowman, Amy Granger, Catherine L. Burgess, Nicola Abo, Shaza Connolly, Bronwen Denehy, Linda J Clin Med Review Background: Growing evidence supports exercise for people with lung cancer. This overview aimed to summarise exercise intervention efficacy and safety across the care continuum. Methods: Eight databases (including Cochrane and Medline) were searched (inception—February 2022) for systematic reviews of RCTs/quasi-RCTs. Eligibility: population—adults with lung cancer; intervention: exercise (e.g., aerobic, resistance) +/− non-exercise (e.g., nutrition); comparator: usual care/non-exercise; primary outcomes: exercise capacity, physical function, health-related quality of life (HRQoL) and post-operative complications. Duplicate, independent title/abstract and full-text screening, data extraction and quality ratings (AMSTAR-2) were completed. Results: Thirty systematic reviews involving between 157 and 2109 participants (n = 6440 total) were included. Most reviews (n = 28) involved surgical participants. Twenty-five reviews performed meta-analyses. The review quality was commonly rated critically low (n = 22) or low (n = 7). Reviews commonly included combinations of aerobic, resistance and/or respiratory exercise interventions. Pre-operative meta-analyses demonstrated that exercise reduces post-operative complications (n = 4/7) and improves exercise capacity (n = 6/6), whilst HRQoL findings were non-significant (n = 3/3). Post-operative meta-analyses reported significant improvements in exercise capacity (n = 2/3) and muscle strength (n = 1/1) and non-significant HRQoL changes (n = 8/10). Interventions delivered to mixed surgical and non-surgical populations improved exercise capacity (n = 3/4), muscle strength (n = 2/2) and HRQoL (n = 3). Meta-analyses of interventions in non-surgical populations demonstrated inconsistent findings. Adverse event rates were low, however, few reviews reported on safety. Conclusions: A large body of evidence supports lung cancer exercise interventions to reduce complications and improve exercise capacity in pre- and post-operative populations. Additional higher-quality research is needed, particularly in the non-surgical population, including subgroup analyses of exercise type and setting. MDPI 2023-02-27 /pmc/articles/PMC10003899/ /pubmed/36902659 http://dx.doi.org/10.3390/jcm12051871 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Edbrooke, Lara Bowman, Amy Granger, Catherine L. Burgess, Nicola Abo, Shaza Connolly, Bronwen Denehy, Linda Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
title | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
title_full | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
title_fullStr | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
title_full_unstemmed | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
title_short | Exercise across the Lung Cancer Care Continuum: An Overview of Systematic Reviews |
title_sort | exercise across the lung cancer care continuum: an overview of systematic reviews |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003899/ https://www.ncbi.nlm.nih.gov/pubmed/36902659 http://dx.doi.org/10.3390/jcm12051871 |
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