Cargando…

The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization

According to the World Health Organization’s definition, long COVID is the persistence or development of new symptoms 3 months after the initial infection. Various conditions have been explored in studies with up to one-year follow-up but very few looked further. This prospective cohort study addres...

Descripción completa

Detalles Bibliográficos
Autores principales: Ranucci, Marco, Baryshnikova, Ekaterina, Anguissola, Martina, Pugliese, Sara, Ranucci, Luca, Falco, Mara, Menicanti, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003916/
https://www.ncbi.nlm.nih.gov/pubmed/36902702
http://dx.doi.org/10.3390/jcm12051915
_version_ 1784904714248257536
author Ranucci, Marco
Baryshnikova, Ekaterina
Anguissola, Martina
Pugliese, Sara
Ranucci, Luca
Falco, Mara
Menicanti, Lorenzo
author_facet Ranucci, Marco
Baryshnikova, Ekaterina
Anguissola, Martina
Pugliese, Sara
Ranucci, Luca
Falco, Mara
Menicanti, Lorenzo
author_sort Ranucci, Marco
collection PubMed
description According to the World Health Organization’s definition, long COVID is the persistence or development of new symptoms 3 months after the initial infection. Various conditions have been explored in studies with up to one-year follow-up but very few looked further. This prospective cohort study addresses the presence of a wide spectrum of symptoms in 121 patients hospitalized during the acute phase of COVID-19 infection, and the association between factors related to the acute phase of the disease and the presence of residual symptoms after one year or longer from hospitalization. The main results are as follows: (i) post-COVID symptoms persist in up to 60% of the patient population at a mean follow-up of 17 months; (ii) the most frequent symptoms are fatigue and dyspnea, but neuropsychological disturbances persist in about 30% of the patients (iii) when corrected for the duration of follow-up with a freedom-from-event analysis; only complete (2 doses) vaccination at the time of hospital admission remained independently associated with persistence of the major physical symptoms, while vaccination and previous neuropsychological symptoms remained independently associated with persistence of major neuropsychological symptoms.
format Online
Article
Text
id pubmed-10003916
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100039162023-03-11 The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization Ranucci, Marco Baryshnikova, Ekaterina Anguissola, Martina Pugliese, Sara Ranucci, Luca Falco, Mara Menicanti, Lorenzo J Clin Med Article According to the World Health Organization’s definition, long COVID is the persistence or development of new symptoms 3 months after the initial infection. Various conditions have been explored in studies with up to one-year follow-up but very few looked further. This prospective cohort study addresses the presence of a wide spectrum of symptoms in 121 patients hospitalized during the acute phase of COVID-19 infection, and the association between factors related to the acute phase of the disease and the presence of residual symptoms after one year or longer from hospitalization. The main results are as follows: (i) post-COVID symptoms persist in up to 60% of the patient population at a mean follow-up of 17 months; (ii) the most frequent symptoms are fatigue and dyspnea, but neuropsychological disturbances persist in about 30% of the patients (iii) when corrected for the duration of follow-up with a freedom-from-event analysis; only complete (2 doses) vaccination at the time of hospital admission remained independently associated with persistence of the major physical symptoms, while vaccination and previous neuropsychological symptoms remained independently associated with persistence of major neuropsychological symptoms. MDPI 2023-02-28 /pmc/articles/PMC10003916/ /pubmed/36902702 http://dx.doi.org/10.3390/jcm12051915 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ranucci, Marco
Baryshnikova, Ekaterina
Anguissola, Martina
Pugliese, Sara
Ranucci, Luca
Falco, Mara
Menicanti, Lorenzo
The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
title The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
title_full The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
title_fullStr The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
title_full_unstemmed The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
title_short The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
title_sort very long covid: persistence of symptoms after 12–18 months from the onset of infection and hospitalization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003916/
https://www.ncbi.nlm.nih.gov/pubmed/36902702
http://dx.doi.org/10.3390/jcm12051915
work_keys_str_mv AT ranuccimarco theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT baryshnikovaekaterina theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT anguissolamartina theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT pugliesesara theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT ranucciluca theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT falcomara theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT menicantilorenzo theverylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT ranuccimarco verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT baryshnikovaekaterina verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT anguissolamartina verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT pugliesesara verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT ranucciluca verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT falcomara verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization
AT menicantilorenzo verylongcovidpersistenceofsymptomsafter1218monthsfromtheonsetofinfectionandhospitalization