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The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization
According to the World Health Organization’s definition, long COVID is the persistence or development of new symptoms 3 months after the initial infection. Various conditions have been explored in studies with up to one-year follow-up but very few looked further. This prospective cohort study addres...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003916/ https://www.ncbi.nlm.nih.gov/pubmed/36902702 http://dx.doi.org/10.3390/jcm12051915 |
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author | Ranucci, Marco Baryshnikova, Ekaterina Anguissola, Martina Pugliese, Sara Ranucci, Luca Falco, Mara Menicanti, Lorenzo |
author_facet | Ranucci, Marco Baryshnikova, Ekaterina Anguissola, Martina Pugliese, Sara Ranucci, Luca Falco, Mara Menicanti, Lorenzo |
author_sort | Ranucci, Marco |
collection | PubMed |
description | According to the World Health Organization’s definition, long COVID is the persistence or development of new symptoms 3 months after the initial infection. Various conditions have been explored in studies with up to one-year follow-up but very few looked further. This prospective cohort study addresses the presence of a wide spectrum of symptoms in 121 patients hospitalized during the acute phase of COVID-19 infection, and the association between factors related to the acute phase of the disease and the presence of residual symptoms after one year or longer from hospitalization. The main results are as follows: (i) post-COVID symptoms persist in up to 60% of the patient population at a mean follow-up of 17 months; (ii) the most frequent symptoms are fatigue and dyspnea, but neuropsychological disturbances persist in about 30% of the patients (iii) when corrected for the duration of follow-up with a freedom-from-event analysis; only complete (2 doses) vaccination at the time of hospital admission remained independently associated with persistence of the major physical symptoms, while vaccination and previous neuropsychological symptoms remained independently associated with persistence of major neuropsychological symptoms. |
format | Online Article Text |
id | pubmed-10003916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100039162023-03-11 The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization Ranucci, Marco Baryshnikova, Ekaterina Anguissola, Martina Pugliese, Sara Ranucci, Luca Falco, Mara Menicanti, Lorenzo J Clin Med Article According to the World Health Organization’s definition, long COVID is the persistence or development of new symptoms 3 months after the initial infection. Various conditions have been explored in studies with up to one-year follow-up but very few looked further. This prospective cohort study addresses the presence of a wide spectrum of symptoms in 121 patients hospitalized during the acute phase of COVID-19 infection, and the association between factors related to the acute phase of the disease and the presence of residual symptoms after one year or longer from hospitalization. The main results are as follows: (i) post-COVID symptoms persist in up to 60% of the patient population at a mean follow-up of 17 months; (ii) the most frequent symptoms are fatigue and dyspnea, but neuropsychological disturbances persist in about 30% of the patients (iii) when corrected for the duration of follow-up with a freedom-from-event analysis; only complete (2 doses) vaccination at the time of hospital admission remained independently associated with persistence of the major physical symptoms, while vaccination and previous neuropsychological symptoms remained independently associated with persistence of major neuropsychological symptoms. MDPI 2023-02-28 /pmc/articles/PMC10003916/ /pubmed/36902702 http://dx.doi.org/10.3390/jcm12051915 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ranucci, Marco Baryshnikova, Ekaterina Anguissola, Martina Pugliese, Sara Ranucci, Luca Falco, Mara Menicanti, Lorenzo The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization |
title | The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization |
title_full | The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization |
title_fullStr | The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization |
title_full_unstemmed | The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization |
title_short | The Very Long COVID: Persistence of Symptoms after 12–18 Months from the Onset of Infection and Hospitalization |
title_sort | very long covid: persistence of symptoms after 12–18 months from the onset of infection and hospitalization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003916/ https://www.ncbi.nlm.nih.gov/pubmed/36902702 http://dx.doi.org/10.3390/jcm12051915 |
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