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Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation

We compared the effects of sex differences in delayed hospitalization (symptom-to-door time [SDT], ≥24 h) on major clinical outcomes in patients with non-ST-segment elevation myocardial infarction after new-generation drug-eluting stent implantation. A total of 4593 patients were classified into gro...

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Autores principales: Kim, Yong Hoon, Her, Ae-Young, Rha, Seung-Woon, Choi, Cheol Ung, Choi, Byoung Geol, Kim, Ji Bak, Park, Soohyung, Kang, Dong Oh, Park, Ji Young, Choi, Woong Gil, Park, Sang-Ho, Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003952/
https://www.ncbi.nlm.nih.gov/pubmed/36902769
http://dx.doi.org/10.3390/jcm12051982
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author Kim, Yong Hoon
Her, Ae-Young
Rha, Seung-Woon
Choi, Cheol Ung
Choi, Byoung Geol
Kim, Ji Bak
Park, Soohyung
Kang, Dong Oh
Park, Ji Young
Choi, Woong Gil
Park, Sang-Ho
Jeong, Myung Ho
author_facet Kim, Yong Hoon
Her, Ae-Young
Rha, Seung-Woon
Choi, Cheol Ung
Choi, Byoung Geol
Kim, Ji Bak
Park, Soohyung
Kang, Dong Oh
Park, Ji Young
Choi, Woong Gil
Park, Sang-Ho
Jeong, Myung Ho
author_sort Kim, Yong Hoon
collection PubMed
description We compared the effects of sex differences in delayed hospitalization (symptom-to-door time [SDT], ≥24 h) on major clinical outcomes in patients with non-ST-segment elevation myocardial infarction after new-generation drug-eluting stent implantation. A total of 4593 patients were classified into groups with (n = 1276) and without delayed hospitalization (SDT < 24 h, n = 3317). Thereafter, these two groups were subdivided into male and female groups. The primary clinical outcomes were major adverse cardiac and cerebrovascular events (MACCE), defined as all-cause death, recurrent myocardial infarction, repeat coronary revascularization, and stroke. The secondary clinical outcome was stent thrombosis. After multivariable- and propensity score-adjusted analyses, in-hospital mortalities were similar between the male and female groups in both the SDT < 24 h and SDT ≥ 24 h groups. However, during a 3-year follow-up period, in the SDT < 24 h group, all-cause death (p = 0.013 and p = 0.005, respectively) and cardiac death (CD, p = 0.015 and p = 0.008, respectively) rates were significantly higher in the female group than those in the male group. This may be related to the lower all-cause death and CD rates (p = 0.022 and p = 0.012, respectively) in the SDT < 24 h group than in the SDT ≥ 24 h group among male patients. Other outcomes were similar between the male and female groups and between the SDT < 24 h and SDT ≥ 24 h groups. In this prospective cohort study, female patients showed higher 3-year mortality, especially in the SDT < 24 h, compared to male patients.
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spelling pubmed-100039522023-03-11 Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation Kim, Yong Hoon Her, Ae-Young Rha, Seung-Woon Choi, Cheol Ung Choi, Byoung Geol Kim, Ji Bak Park, Soohyung Kang, Dong Oh Park, Ji Young Choi, Woong Gil Park, Sang-Ho Jeong, Myung Ho J Clin Med Article We compared the effects of sex differences in delayed hospitalization (symptom-to-door time [SDT], ≥24 h) on major clinical outcomes in patients with non-ST-segment elevation myocardial infarction after new-generation drug-eluting stent implantation. A total of 4593 patients were classified into groups with (n = 1276) and without delayed hospitalization (SDT < 24 h, n = 3317). Thereafter, these two groups were subdivided into male and female groups. The primary clinical outcomes were major adverse cardiac and cerebrovascular events (MACCE), defined as all-cause death, recurrent myocardial infarction, repeat coronary revascularization, and stroke. The secondary clinical outcome was stent thrombosis. After multivariable- and propensity score-adjusted analyses, in-hospital mortalities were similar between the male and female groups in both the SDT < 24 h and SDT ≥ 24 h groups. However, during a 3-year follow-up period, in the SDT < 24 h group, all-cause death (p = 0.013 and p = 0.005, respectively) and cardiac death (CD, p = 0.015 and p = 0.008, respectively) rates were significantly higher in the female group than those in the male group. This may be related to the lower all-cause death and CD rates (p = 0.022 and p = 0.012, respectively) in the SDT < 24 h group than in the SDT ≥ 24 h group among male patients. Other outcomes were similar between the male and female groups and between the SDT < 24 h and SDT ≥ 24 h groups. In this prospective cohort study, female patients showed higher 3-year mortality, especially in the SDT < 24 h, compared to male patients. MDPI 2023-03-02 /pmc/articles/PMC10003952/ /pubmed/36902769 http://dx.doi.org/10.3390/jcm12051982 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Yong Hoon
Her, Ae-Young
Rha, Seung-Woon
Choi, Cheol Ung
Choi, Byoung Geol
Kim, Ji Bak
Park, Soohyung
Kang, Dong Oh
Park, Ji Young
Choi, Woong Gil
Park, Sang-Ho
Jeong, Myung Ho
Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_full Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_fullStr Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_full_unstemmed Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_short Sex Differences in Delayed Hospitalization in Patients with Non-ST-Segment Elevation Myocardial Infarction Undergoing New-Generation Drug-Eluting Stent Implantation
title_sort sex differences in delayed hospitalization in patients with non-st-segment elevation myocardial infarction undergoing new-generation drug-eluting stent implantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003952/
https://www.ncbi.nlm.nih.gov/pubmed/36902769
http://dx.doi.org/10.3390/jcm12051982
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