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Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy

Ischemic heart failure (HF) is one of the most common causes of morbidity and mortality in the world-wide, but sex-specific predictors of mortality in elderly patients with ischemic cardiomyopathy (ICMP) have been poorly studied. A total of 536 patients with ICMP over 65 years-old (77.8 ± 7.1 years,...

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Autores principales: Yoon, Hyun Ju, Kim, Kye Hun, Lee, Nuri, Park, Hyukjin, Kim, Hyung Yoon, Cho, Jae Yeong, Ahn, Youngkeun, Jeong, Myung Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003953/
https://www.ncbi.nlm.nih.gov/pubmed/36902797
http://dx.doi.org/10.3390/jcm12052012
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author Yoon, Hyun Ju
Kim, Kye Hun
Lee, Nuri
Park, Hyukjin
Kim, Hyung Yoon
Cho, Jae Yeong
Ahn, Youngkeun
Jeong, Myung Ho
author_facet Yoon, Hyun Ju
Kim, Kye Hun
Lee, Nuri
Park, Hyukjin
Kim, Hyung Yoon
Cho, Jae Yeong
Ahn, Youngkeun
Jeong, Myung Ho
author_sort Yoon, Hyun Ju
collection PubMed
description Ischemic heart failure (HF) is one of the most common causes of morbidity and mortality in the world-wide, but sex-specific predictors of mortality in elderly patients with ischemic cardiomyopathy (ICMP) have been poorly studied. A total of 536 patients with ICMP over 65 years-old (77.8 ± 7.1 years, 283 males) were followed for a mean of 5.4 years. The development of death during clinical follow up was evaluated, and predictors of mortality were compared. Death was developed in 137 patients (25.6%); 64 females (25.3%) vs. 73 males (25.8%). Low-ejection fraction was only an independent predictor of mortality in ICMP, regardless of sex (HR 3.070 CI = 1.708–5.520 in female, HR 2.011, CI = 1.146–3.527 in male). Diabetes (HR 1.811, CI = 1.016–3.229), elevated e/e’ (HR 2.479, CI = 1.201–5.117), elevated pulmonary artery systolic pressure (HR 2.833, CI = 1.197–6.704), anemia (HR 1.860, CI = 1.025–3.373), beta blocker non-use (HR2.148, CI = 1.010–4.568), and angiotensin receptor blocker non-use (HR 2.100, CI = 1.137–3.881) were bad prognostic factors of long term mortality in female, whereas hypertension (HR 1.770, CI = 1.024–3.058), elevated Creatinine (HR 2.188, CI = 1.225–3.908), and statin non-use (HR 3.475, CI = 1.989–6.071) were predictors of mortality in males with ICMP independently. Systolic dysfunction in both sexes, diastolic dysfunction, beta blocker and angiotensin receptor blockers in female, and statins in males have important roles for long-term mortality in elderly patients with ICMP. For improving long-term survival in elderly patients with ICMP, it may be necessary to approach sex specifically.
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spelling pubmed-100039532023-03-11 Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy Yoon, Hyun Ju Kim, Kye Hun Lee, Nuri Park, Hyukjin Kim, Hyung Yoon Cho, Jae Yeong Ahn, Youngkeun Jeong, Myung Ho J Clin Med Article Ischemic heart failure (HF) is one of the most common causes of morbidity and mortality in the world-wide, but sex-specific predictors of mortality in elderly patients with ischemic cardiomyopathy (ICMP) have been poorly studied. A total of 536 patients with ICMP over 65 years-old (77.8 ± 7.1 years, 283 males) were followed for a mean of 5.4 years. The development of death during clinical follow up was evaluated, and predictors of mortality were compared. Death was developed in 137 patients (25.6%); 64 females (25.3%) vs. 73 males (25.8%). Low-ejection fraction was only an independent predictor of mortality in ICMP, regardless of sex (HR 3.070 CI = 1.708–5.520 in female, HR 2.011, CI = 1.146–3.527 in male). Diabetes (HR 1.811, CI = 1.016–3.229), elevated e/e’ (HR 2.479, CI = 1.201–5.117), elevated pulmonary artery systolic pressure (HR 2.833, CI = 1.197–6.704), anemia (HR 1.860, CI = 1.025–3.373), beta blocker non-use (HR2.148, CI = 1.010–4.568), and angiotensin receptor blocker non-use (HR 2.100, CI = 1.137–3.881) were bad prognostic factors of long term mortality in female, whereas hypertension (HR 1.770, CI = 1.024–3.058), elevated Creatinine (HR 2.188, CI = 1.225–3.908), and statin non-use (HR 3.475, CI = 1.989–6.071) were predictors of mortality in males with ICMP independently. Systolic dysfunction in both sexes, diastolic dysfunction, beta blocker and angiotensin receptor blockers in female, and statins in males have important roles for long-term mortality in elderly patients with ICMP. For improving long-term survival in elderly patients with ICMP, it may be necessary to approach sex specifically. MDPI 2023-03-03 /pmc/articles/PMC10003953/ /pubmed/36902797 http://dx.doi.org/10.3390/jcm12052012 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoon, Hyun Ju
Kim, Kye Hun
Lee, Nuri
Park, Hyukjin
Kim, Hyung Yoon
Cho, Jae Yeong
Ahn, Youngkeun
Jeong, Myung Ho
Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy
title Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy
title_full Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy
title_fullStr Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy
title_full_unstemmed Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy
title_short Sex-Specific Predictors of Long-Term Mortality in Elderly Patients with Ischemic Cardiomyopathy
title_sort sex-specific predictors of long-term mortality in elderly patients with ischemic cardiomyopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003953/
https://www.ncbi.nlm.nih.gov/pubmed/36902797
http://dx.doi.org/10.3390/jcm12052012
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