Importance of the 2,6-Difluorobenzamide Motif for FtsZ Allosteric Inhibition: Insights from Conformational Analysis, Molecular Docking and Structural Modifications

A conformational analysis and molecular docking study comparing 2,6-difluoro-3-methoxybenzamide (DFMBA) with 3-methoxybenzamide (3-MBA) has been undertaken for investigating the known increase of FtsZ inhibition related anti S. aureus activity due to fluorination. For the isolated molecules, the cal...

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Detalles Bibliográficos
Autores principales: Barbier, Thibaut, Dumitrescu, Oana, Lina, Gérard, Queneau, Yves, Soulère, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003973/
https://www.ncbi.nlm.nih.gov/pubmed/36903302
http://dx.doi.org/10.3390/molecules28052055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003973/
https://www.ncbi.nlm.nih.gov/pubmed/36903302
http://dx.doi.org/10.3390/molecules28052055

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