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Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract

Background: This study aimed to assess the prevalence and course of endometriosis in adolescents with obstructive Müllerian anomalies. Methods: The study group involved 50 adolescents undergoing surgeries (median age 13.5 (range 11.1–18.5)) for rare obstructive malformations of the genital tract: 15...

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Autores principales: Kapczuk, Karina, Zajączkowska, Weronika, Madziar, Klaudyna, Kędzia, Witold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003989/
https://www.ncbi.nlm.nih.gov/pubmed/36902794
http://dx.doi.org/10.3390/jcm12052007
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author Kapczuk, Karina
Zajączkowska, Weronika
Madziar, Klaudyna
Kędzia, Witold
author_facet Kapczuk, Karina
Zajączkowska, Weronika
Madziar, Klaudyna
Kędzia, Witold
author_sort Kapczuk, Karina
collection PubMed
description Background: This study aimed to assess the prevalence and course of endometriosis in adolescents with obstructive Müllerian anomalies. Methods: The study group involved 50 adolescents undergoing surgeries (median age 13.5 (range 11.1–18.5)) for rare obstructive malformations of the genital tract: 15 girls had anomalies associated with cryptomenorrhea and 35 were menstruating. The median follow-up period was 2.4 (ranging from 0.1 to 9.5) years. Results: We diagnosed endometriosis in 23 of the 50 subjects (46%), including 10 of the 23 patients (43.5%) with obstructed hemivagina ipsilateral renal anomaly syndrome (OHVIRAS), six of eight patients (75%) with a unicornuate uterus with a non-communicating functional horn, two of three patients (66.7%) with distal vaginal aplasia, and five of five patients (100%) with cervicovaginal aplasia. Persistent dysmenorrhea, following treatment, affected 14 of the 50 adolescents (28%), including 8 of the 17 subjects (47.1%) diagnosed with endometriosis at the time of surgical correction and six adolescents diagnosed with endometriosis during the follow-up. Conclusions: Endometriosis affects about half of young adolescents undergoing surgical treatment of obstructive Müllerian anomalies after menarche. The incidence of endometriosis is highest in girls with cervical aplasia. The risk of developing endometriosis decreases after surgical correction of obstruction but is still significant in patients with uterine anomalies.
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spelling pubmed-100039892023-03-11 Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract Kapczuk, Karina Zajączkowska, Weronika Madziar, Klaudyna Kędzia, Witold J Clin Med Article Background: This study aimed to assess the prevalence and course of endometriosis in adolescents with obstructive Müllerian anomalies. Methods: The study group involved 50 adolescents undergoing surgeries (median age 13.5 (range 11.1–18.5)) for rare obstructive malformations of the genital tract: 15 girls had anomalies associated with cryptomenorrhea and 35 were menstruating. The median follow-up period was 2.4 (ranging from 0.1 to 9.5) years. Results: We diagnosed endometriosis in 23 of the 50 subjects (46%), including 10 of the 23 patients (43.5%) with obstructed hemivagina ipsilateral renal anomaly syndrome (OHVIRAS), six of eight patients (75%) with a unicornuate uterus with a non-communicating functional horn, two of three patients (66.7%) with distal vaginal aplasia, and five of five patients (100%) with cervicovaginal aplasia. Persistent dysmenorrhea, following treatment, affected 14 of the 50 adolescents (28%), including 8 of the 17 subjects (47.1%) diagnosed with endometriosis at the time of surgical correction and six adolescents diagnosed with endometriosis during the follow-up. Conclusions: Endometriosis affects about half of young adolescents undergoing surgical treatment of obstructive Müllerian anomalies after menarche. The incidence of endometriosis is highest in girls with cervical aplasia. The risk of developing endometriosis decreases after surgical correction of obstruction but is still significant in patients with uterine anomalies. MDPI 2023-03-03 /pmc/articles/PMC10003989/ /pubmed/36902794 http://dx.doi.org/10.3390/jcm12052007 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kapczuk, Karina
Zajączkowska, Weronika
Madziar, Klaudyna
Kędzia, Witold
Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract
title Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract
title_full Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract
title_fullStr Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract
title_full_unstemmed Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract
title_short Endometriosis in Adolescents with Obstructive Anomalies of the Reproductive Tract
title_sort endometriosis in adolescents with obstructive anomalies of the reproductive tract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10003989/
https://www.ncbi.nlm.nih.gov/pubmed/36902794
http://dx.doi.org/10.3390/jcm12052007
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