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Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis

(1) Purpose: A patient with scleritis may have an associated systemic disease, which is often autoimmunological and seldom infectious in origin. The data regarding such associations in Hispanic populations are scarce. Therefore, we evaluated the clinical characteristics and systemic-disease associat...

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Autores principales: Arruza, Cristina, Requejo Figueroa, Guillermo A., Colón, Javier, Ramirez Marquez, Estefania, Puebla, Guillermo, Ortega, Daniela, Pappaterra Rodriguez, Mariella, López Fontanet, José, Colón, Alexandra, Ayala Rodríguez, Sofía C., Rivera Grana, Erick, Marrero, Frances, Báez, Emilio, Santos, Carmen, Oliver, Armando L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004097/
https://www.ncbi.nlm.nih.gov/pubmed/36902755
http://dx.doi.org/10.3390/jcm12051969
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author Arruza, Cristina
Requejo Figueroa, Guillermo A.
Colón, Javier
Ramirez Marquez, Estefania
Puebla, Guillermo
Ortega, Daniela
Pappaterra Rodriguez, Mariella
López Fontanet, José
Colón, Alexandra
Ayala Rodríguez, Sofía C.
Rivera Grana, Erick
Marrero, Frances
Báez, Emilio
Santos, Carmen
Oliver, Armando L.
author_facet Arruza, Cristina
Requejo Figueroa, Guillermo A.
Colón, Javier
Ramirez Marquez, Estefania
Puebla, Guillermo
Ortega, Daniela
Pappaterra Rodriguez, Mariella
López Fontanet, José
Colón, Alexandra
Ayala Rodríguez, Sofía C.
Rivera Grana, Erick
Marrero, Frances
Báez, Emilio
Santos, Carmen
Oliver, Armando L.
author_sort Arruza, Cristina
collection PubMed
description (1) Purpose: A patient with scleritis may have an associated systemic disease, which is often autoimmunological and seldom infectious in origin. The data regarding such associations in Hispanic populations are scarce. Therefore, we evaluated the clinical characteristics and systemic-disease associations of a cohort of Hispanic patients with scleritis. (2) Methods: A retrospective review of the medical records (January 1990–July 2021) of two private uveitis practices in Puerto Rico was performed. Clinical characteristics and systemic-disease associations observed either at presentation or diagnosed as a consequence of the initial workup were recorded. (3) Results: A total of 178 eyes of 141 patients diagnosed with scleritis were identified. An associated autoimmune disease was present in 33.3% of the patients (rheumatoid arthritis, 22.7%; Sjögren’s syndrome, 3.5%; relapsing polychondritis, 2.8%; sarcoidosis, 1.4%; systemic lupus erythematosus, 1.4%; and systemic vasculitis, 0.7%). An associated infectious disease was present in 5.7% of the patients (2.13%, syphilis; 1.41%, herpes simplex; 1.14%, herpes zoster; and 0.71%, Lyme disease). One patient had all-trans retinoic-acid-associated scleritis. Statistical analysis revealed that patients with nodular anterior scleritis were less likely to have an associated immune-mediated disease (OR: 0.21; p = 0.011). (4) Conclusion: Rheumatoid arthritis was the most common systemic autoimmune disease association, while syphilis was the most common infectious disease associated with scleritis patients. Our study suggests that patients with nodular scleritis have a lower risk of having an associated immune-mediated disease.
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spelling pubmed-100040972023-03-11 Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis Arruza, Cristina Requejo Figueroa, Guillermo A. Colón, Javier Ramirez Marquez, Estefania Puebla, Guillermo Ortega, Daniela Pappaterra Rodriguez, Mariella López Fontanet, José Colón, Alexandra Ayala Rodríguez, Sofía C. Rivera Grana, Erick Marrero, Frances Báez, Emilio Santos, Carmen Oliver, Armando L. J Clin Med Article (1) Purpose: A patient with scleritis may have an associated systemic disease, which is often autoimmunological and seldom infectious in origin. The data regarding such associations in Hispanic populations are scarce. Therefore, we evaluated the clinical characteristics and systemic-disease associations of a cohort of Hispanic patients with scleritis. (2) Methods: A retrospective review of the medical records (January 1990–July 2021) of two private uveitis practices in Puerto Rico was performed. Clinical characteristics and systemic-disease associations observed either at presentation or diagnosed as a consequence of the initial workup were recorded. (3) Results: A total of 178 eyes of 141 patients diagnosed with scleritis were identified. An associated autoimmune disease was present in 33.3% of the patients (rheumatoid arthritis, 22.7%; Sjögren’s syndrome, 3.5%; relapsing polychondritis, 2.8%; sarcoidosis, 1.4%; systemic lupus erythematosus, 1.4%; and systemic vasculitis, 0.7%). An associated infectious disease was present in 5.7% of the patients (2.13%, syphilis; 1.41%, herpes simplex; 1.14%, herpes zoster; and 0.71%, Lyme disease). One patient had all-trans retinoic-acid-associated scleritis. Statistical analysis revealed that patients with nodular anterior scleritis were less likely to have an associated immune-mediated disease (OR: 0.21; p = 0.011). (4) Conclusion: Rheumatoid arthritis was the most common systemic autoimmune disease association, while syphilis was the most common infectious disease associated with scleritis patients. Our study suggests that patients with nodular scleritis have a lower risk of having an associated immune-mediated disease. MDPI 2023-03-02 /pmc/articles/PMC10004097/ /pubmed/36902755 http://dx.doi.org/10.3390/jcm12051969 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arruza, Cristina
Requejo Figueroa, Guillermo A.
Colón, Javier
Ramirez Marquez, Estefania
Puebla, Guillermo
Ortega, Daniela
Pappaterra Rodriguez, Mariella
López Fontanet, José
Colón, Alexandra
Ayala Rodríguez, Sofía C.
Rivera Grana, Erick
Marrero, Frances
Báez, Emilio
Santos, Carmen
Oliver, Armando L.
Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis
title Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis
title_full Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis
title_fullStr Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis
title_full_unstemmed Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis
title_short Systemic Disease Associations in a Cohort of Hispanic Patients with Scleritis
title_sort systemic disease associations in a cohort of hispanic patients with scleritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004097/
https://www.ncbi.nlm.nih.gov/pubmed/36902755
http://dx.doi.org/10.3390/jcm12051969
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