Prospective of Agro-Waste Husks for Biogenic Synthesis of Polymeric-Based CeO(2)/NiO Nanocomposite Sensor for Determination of Mebeverine Hydrochloride

Background: The remarkable properties of nickel oxide (NiO) and cerium oxide (CeO(2)) nanostructures have attracted considerable interest in these nanocomposites as potential electroactive materials for sensor construction. Methods: The mebeverine hydrochloride (MBHCl) content of commercial formulations was determined in this study using a unique factionalized CeO(2)/NiO-nanocomposite-coated membrane sensor. Results: Mebeverine-phosphotungstate (MB-PT) was prepared by adding phosphotungstic acid to mebeverine hydrochloride and mixing with a polymeric matrix (polyvinyl chloride, PVC) and plasticizing agent o-nitrophenyl octyl ether. The new suggested sensor showed an excellent linear detection range of the selected analyte at 1.0 × 10(−8)–1.0 × 10(−2) mol L(−1) with regression equation E(mV) = (−29.429 ± 0.2) log [MB] + 347.86. However, the unfunctionalized sensor MB–PT displayed less linearity at 1.0 × 10(−5–)1.0 × 10(−2) mol L(−1) drug solution with regression equation E(mV) = (−26.603 ± 0.5) log [MB] + 256.81. By considering a number of factors, the applicability and validity of the suggested potentiometric system were improved following the rules of analytical methodological requirements. Conclusion: The created potentiometric technique worked well for determining MB in bulk substance and in medical commercial samples.