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Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings
Wound care is a global health issue with a financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Although there are more than 3000 dressing types in the wound management market, new devel...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004169/ https://www.ncbi.nlm.nih.gov/pubmed/36839966 http://dx.doi.org/10.3390/pharmaceutics15020644 |
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author | Firoozbahr, Meysam Kingshott, Peter Palombo, Enzo A. Zaferanloo, Bita |
author_facet | Firoozbahr, Meysam Kingshott, Peter Palombo, Enzo A. Zaferanloo, Bita |
author_sort | Firoozbahr, Meysam |
collection | PubMed |
description | Wound care is a global health issue with a financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Although there are more than 3000 dressing types in the wound management market, new developments in more efficient wound dressings will require innovative approaches such as embedding antibacterial additives into wound-dressing materials. The lack of novel antibacterial agents and the misuse of current antibiotics have caused an increase in antimicrobial resistance (AMR) which is estimated to cause 10 million deaths by 2050 worldwide. These ongoing challenges clearly indicate an urgent need for developing new antibacterial additives in wound dressings targeting microbial pathogens. Natural products and their derivatives have long been a significant source of pharmaceuticals against AMR. Scrutinising the data of newly approved drugs has identified plants as one of the biggest and most important sources in the development of novel antibacterial drugs. Some of the plant-based antibacterial additives, such as essential oils and plant extracts, have been previously used in wound dressings; however, there is another source of plant-derived antibacterial additives, i.e., those produced by symbiotic endophytic fungi, that show great potential in wound dressing applications. Endophytes represent a novel, natural, and sustainable source of bioactive compounds for therapeutic applications, including as efficient antibacterial additives for chronic wound dressings. This review examines and appraises recent developments in bioactive wound dressings that incorporate natural products as antibacterial agents as well as advances in endophyte research that show great potential in treating chronic wounds. |
format | Online Article Text |
id | pubmed-10004169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100041692023-03-11 Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings Firoozbahr, Meysam Kingshott, Peter Palombo, Enzo A. Zaferanloo, Bita Pharmaceutics Review Wound care is a global health issue with a financial burden of up to US $96.8 billion annually in the USA alone. Chronic non-healing wounds which show delayed and incomplete healing are especially problematic. Although there are more than 3000 dressing types in the wound management market, new developments in more efficient wound dressings will require innovative approaches such as embedding antibacterial additives into wound-dressing materials. The lack of novel antibacterial agents and the misuse of current antibiotics have caused an increase in antimicrobial resistance (AMR) which is estimated to cause 10 million deaths by 2050 worldwide. These ongoing challenges clearly indicate an urgent need for developing new antibacterial additives in wound dressings targeting microbial pathogens. Natural products and their derivatives have long been a significant source of pharmaceuticals against AMR. Scrutinising the data of newly approved drugs has identified plants as one of the biggest and most important sources in the development of novel antibacterial drugs. Some of the plant-based antibacterial additives, such as essential oils and plant extracts, have been previously used in wound dressings; however, there is another source of plant-derived antibacterial additives, i.e., those produced by symbiotic endophytic fungi, that show great potential in wound dressing applications. Endophytes represent a novel, natural, and sustainable source of bioactive compounds for therapeutic applications, including as efficient antibacterial additives for chronic wound dressings. This review examines and appraises recent developments in bioactive wound dressings that incorporate natural products as antibacterial agents as well as advances in endophyte research that show great potential in treating chronic wounds. MDPI 2023-02-14 /pmc/articles/PMC10004169/ /pubmed/36839966 http://dx.doi.org/10.3390/pharmaceutics15020644 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Firoozbahr, Meysam Kingshott, Peter Palombo, Enzo A. Zaferanloo, Bita Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings |
title | Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings |
title_full | Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings |
title_fullStr | Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings |
title_full_unstemmed | Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings |
title_short | Recent Advances in Using Natural Antibacterial Additives in Bioactive Wound Dressings |
title_sort | recent advances in using natural antibacterial additives in bioactive wound dressings |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004169/ https://www.ncbi.nlm.nih.gov/pubmed/36839966 http://dx.doi.org/10.3390/pharmaceutics15020644 |
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