Cargando…

Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study

The aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Marzuillo, Pierluigi, Palma, Pier Luigi, Di Sessa, Anna, Roberti, Agnese, Torino, Giovanni, De Lucia, Maeva, Miraglia del Giudice, Emanuele, Guarino, Stefano, Di Iorio, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004170/
https://www.ncbi.nlm.nih.gov/pubmed/36902711
http://dx.doi.org/10.3390/jcm12051921
_version_ 1784904767365971968
author Marzuillo, Pierluigi
Palma, Pier Luigi
Di Sessa, Anna
Roberti, Agnese
Torino, Giovanni
De Lucia, Maeva
Miraglia del Giudice, Emanuele
Guarino, Stefano
Di Iorio, Giovanni
author_facet Marzuillo, Pierluigi
Palma, Pier Luigi
Di Sessa, Anna
Roberti, Agnese
Torino, Giovanni
De Lucia, Maeva
Miraglia del Giudice, Emanuele
Guarino, Stefano
Di Iorio, Giovanni
author_sort Marzuillo, Pierluigi
collection PubMed
description The aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life with suspected obstructive CAKUT were prospectively enrolled. The patients underwent a 2-year follow-up and were classified as patients needing or not needing surgery. In all of the enrolled patients, PRA and serum aldosterone levels were measured at 1–3 months of life and were evaluated as predictors of surgery by receiver-operating characteristic (ROC) curve analysis. Patients undergoing surgery during follow-up showed significantly higher levels of aldosterone at 1–3 months of life compared to those who did not require surgery (p = 0.006). The ROC curve analysis of the aldosterone for obstructive CAKUT needing surgery showed an area under the ROC curve of 0.88 (95%CI = 0.71–0.95; p = 0.001). The aldosterone cut-off of 100 ng/dL presented 100% sensitivity and 64.3% specificity and predicted surgery in 100% of cases. The PRA at 1–3 months of life was not a predictor of surgery. In conclusion, serum aldosterone levels at 1–3 months could predict the need for surgery during obstructive CAKUT follow-up.
format Online
Article
Text
id pubmed-10004170
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100041702023-03-11 Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study Marzuillo, Pierluigi Palma, Pier Luigi Di Sessa, Anna Roberti, Agnese Torino, Giovanni De Lucia, Maeva Miraglia del Giudice, Emanuele Guarino, Stefano Di Iorio, Giovanni J Clin Med Brief Report The aim of the study was to evaluate whether serum aldosterone levels or plasmatic renin activity (PRA) measured early in life (1–3 months) could predict a future surgical intervention for obstructive congenital anomalies of kidney and urinary tract (CAKUT). Twenty babies aged 1–3 months of life with suspected obstructive CAKUT were prospectively enrolled. The patients underwent a 2-year follow-up and were classified as patients needing or not needing surgery. In all of the enrolled patients, PRA and serum aldosterone levels were measured at 1–3 months of life and were evaluated as predictors of surgery by receiver-operating characteristic (ROC) curve analysis. Patients undergoing surgery during follow-up showed significantly higher levels of aldosterone at 1–3 months of life compared to those who did not require surgery (p = 0.006). The ROC curve analysis of the aldosterone for obstructive CAKUT needing surgery showed an area under the ROC curve of 0.88 (95%CI = 0.71–0.95; p = 0.001). The aldosterone cut-off of 100 ng/dL presented 100% sensitivity and 64.3% specificity and predicted surgery in 100% of cases. The PRA at 1–3 months of life was not a predictor of surgery. In conclusion, serum aldosterone levels at 1–3 months could predict the need for surgery during obstructive CAKUT follow-up. MDPI 2023-02-28 /pmc/articles/PMC10004170/ /pubmed/36902711 http://dx.doi.org/10.3390/jcm12051921 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Marzuillo, Pierluigi
Palma, Pier Luigi
Di Sessa, Anna
Roberti, Agnese
Torino, Giovanni
De Lucia, Maeva
Miraglia del Giudice, Emanuele
Guarino, Stefano
Di Iorio, Giovanni
Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
title Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
title_full Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
title_fullStr Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
title_full_unstemmed Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
title_short Early-in-Life Serum Aldosterone Levels Could Predict Surgery in Patients with Obstructive Congenital Anomalies of the Kidney and Urinary Tract: A Pilot Study
title_sort early-in-life serum aldosterone levels could predict surgery in patients with obstructive congenital anomalies of the kidney and urinary tract: a pilot study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004170/
https://www.ncbi.nlm.nih.gov/pubmed/36902711
http://dx.doi.org/10.3390/jcm12051921
work_keys_str_mv AT marzuillopierluigi earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT palmapierluigi earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT disessaanna earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT robertiagnese earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT torinogiovanni earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT deluciamaeva earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT miragliadelgiudiceemanuele earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT guarinostefano earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy
AT diioriogiovanni earlyinlifeserumaldosteronelevelscouldpredictsurgeryinpatientswithobstructivecongenitalanomaliesofthekidneyandurinarytractapilotstudy