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Evaluation of comorbid diseases in obstructive sleep apnea syndrome

OBJECTIVE: It is known that obstructive sleep apnea syndrome affects many systems due to hypoxemia and hypercarbia. We aimed to demonstrate with the utilization of well-standardized questionnaire tools and electrophysiological tests that cognitive impairment, depression, autonomic dysfunction, and m...

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Autores principales: Akarsu, Fatma Ger, Algin, Demet Ilhan, Erdinç, Oğuz Osman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Médica Brasileira 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004285/
https://www.ncbi.nlm.nih.gov/pubmed/36820771
http://dx.doi.org/10.1590/1806-9282.20221082
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author Akarsu, Fatma Ger
Algin, Demet Ilhan
Erdinç, Oğuz Osman
author_facet Akarsu, Fatma Ger
Algin, Demet Ilhan
Erdinç, Oğuz Osman
author_sort Akarsu, Fatma Ger
collection PubMed
description OBJECTIVE: It is known that obstructive sleep apnea syndrome affects many systems due to hypoxemia and hypercarbia. We aimed to demonstrate with the utilization of well-standardized questionnaire tools and electrophysiological tests that cognitive impairment, depression, autonomic dysfunction, and metabolic syndrome may occur in association with obstructive sleep apnea syndrome. METHODS: The electrophysiological examination protocol of autonomic nervous system functions was performed with sympathetic skin response and R-R Interval. Patients were administered Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Montreal Cognitive Assessment, and Hamilton Depression Rating Scale by physicians in face-to-face interviews. RESULTS: This study included 148 participants, consisting of 73 patients and 75 controls. There was a statistically significant difference between the patient group and control group with regard to sympathetic skin response, R-R Interval, post-hyperventilation R-R Interval, and R-R Interval variation (p<0.001). A statistically significant difference was observed between the patient group and control group in terms of median Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Montreal Cognitive Assessment scores. It was observed that the control group achieved significantly better scores than the patient group in delayed recall (p<0.001) and language (p<0.05) categories. CONCLUSION: Obstructive sleep apnea syndrome patients should be screened for diseases, especially in the cardiovascular system, that cause serious morbidity and impair functionality such as dementia and depression. We believe that many comorbid diseases encountered in obstructive sleep apnea syndrome patients can be prevented with early diagnosis and continuous positive airway pressure treatment.
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spelling pubmed-100042852023-03-11 Evaluation of comorbid diseases in obstructive sleep apnea syndrome Akarsu, Fatma Ger Algin, Demet Ilhan Erdinç, Oğuz Osman Rev Assoc Med Bras (1992) Original Article OBJECTIVE: It is known that obstructive sleep apnea syndrome affects many systems due to hypoxemia and hypercarbia. We aimed to demonstrate with the utilization of well-standardized questionnaire tools and electrophysiological tests that cognitive impairment, depression, autonomic dysfunction, and metabolic syndrome may occur in association with obstructive sleep apnea syndrome. METHODS: The electrophysiological examination protocol of autonomic nervous system functions was performed with sympathetic skin response and R-R Interval. Patients were administered Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Montreal Cognitive Assessment, and Hamilton Depression Rating Scale by physicians in face-to-face interviews. RESULTS: This study included 148 participants, consisting of 73 patients and 75 controls. There was a statistically significant difference between the patient group and control group with regard to sympathetic skin response, R-R Interval, post-hyperventilation R-R Interval, and R-R Interval variation (p<0.001). A statistically significant difference was observed between the patient group and control group in terms of median Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Montreal Cognitive Assessment scores. It was observed that the control group achieved significantly better scores than the patient group in delayed recall (p<0.001) and language (p<0.05) categories. CONCLUSION: Obstructive sleep apnea syndrome patients should be screened for diseases, especially in the cardiovascular system, that cause serious morbidity and impair functionality such as dementia and depression. We believe that many comorbid diseases encountered in obstructive sleep apnea syndrome patients can be prevented with early diagnosis and continuous positive airway pressure treatment. Associação Médica Brasileira 2023-02-20 /pmc/articles/PMC10004285/ /pubmed/36820771 http://dx.doi.org/10.1590/1806-9282.20221082 Text en https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Akarsu, Fatma Ger
Algin, Demet Ilhan
Erdinç, Oğuz Osman
Evaluation of comorbid diseases in obstructive sleep apnea syndrome
title Evaluation of comorbid diseases in obstructive sleep apnea syndrome
title_full Evaluation of comorbid diseases in obstructive sleep apnea syndrome
title_fullStr Evaluation of comorbid diseases in obstructive sleep apnea syndrome
title_full_unstemmed Evaluation of comorbid diseases in obstructive sleep apnea syndrome
title_short Evaluation of comorbid diseases in obstructive sleep apnea syndrome
title_sort evaluation of comorbid diseases in obstructive sleep apnea syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004285/
https://www.ncbi.nlm.nih.gov/pubmed/36820771
http://dx.doi.org/10.1590/1806-9282.20221082
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