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Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids

Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide–alkyne cycloaddition reacti...

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Autores principales: Manoharan, Gririraj, Bösel, Petra, Thien, Jannis, Holtmannspötter, Michael, Meingast, Laura, Schmidt, Mercedes, Eickmeier, Henning, Haase, Markus, Maultzsch, Janina, Steinhart, Martin, Wollschläger, Joachim, Palma, Matteo, Meyer, Carola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004328/
https://www.ncbi.nlm.nih.gov/pubmed/36903408
http://dx.doi.org/10.3390/molecules28052161
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author Manoharan, Gririraj
Bösel, Petra
Thien, Jannis
Holtmannspötter, Michael
Meingast, Laura
Schmidt, Mercedes
Eickmeier, Henning
Haase, Markus
Maultzsch, Janina
Steinhart, Martin
Wollschläger, Joachim
Palma, Matteo
Meyer, Carola
author_facet Manoharan, Gririraj
Bösel, Petra
Thien, Jannis
Holtmannspötter, Michael
Meingast, Laura
Schmidt, Mercedes
Eickmeier, Henning
Haase, Markus
Maultzsch, Janina
Steinhart, Martin
Wollschläger, Joachim
Palma, Matteo
Meyer, Carola
author_sort Manoharan, Gririraj
collection PubMed
description Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide–alkyne cycloaddition reactions (SPACC). This was characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy and Fourier transform infra-red spectroscopy. Silane–azide-functionalized SWNTs were immobilized from solution onto patterned substrates through dielectrophoresis (DEP). We demonstrate the general applicability of our strategy for the functionalization of SWNTs with metal nanoparticles (gold nanoparticles), fluorescent dyes (Alexa Fluor 647) and biomolecules (aptamers). In this regard, dopamine-binding aptamers were conjugated to the functionalized SWNTs to perform real-time detection of dopamine at different concentrations. Additionally, the chemical route is shown to selectively functionalize individual nanotubes grown on the surface of silicon substrates, contributing towards future nano electronic device applications.
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spelling pubmed-100043282023-03-11 Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids Manoharan, Gririraj Bösel, Petra Thien, Jannis Holtmannspötter, Michael Meingast, Laura Schmidt, Mercedes Eickmeier, Henning Haase, Markus Maultzsch, Janina Steinhart, Martin Wollschläger, Joachim Palma, Matteo Meyer, Carola Molecules Article Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide–alkyne cycloaddition reactions (SPACC). This was characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy and Fourier transform infra-red spectroscopy. Silane–azide-functionalized SWNTs were immobilized from solution onto patterned substrates through dielectrophoresis (DEP). We demonstrate the general applicability of our strategy for the functionalization of SWNTs with metal nanoparticles (gold nanoparticles), fluorescent dyes (Alexa Fluor 647) and biomolecules (aptamers). In this regard, dopamine-binding aptamers were conjugated to the functionalized SWNTs to perform real-time detection of dopamine at different concentrations. Additionally, the chemical route is shown to selectively functionalize individual nanotubes grown on the surface of silicon substrates, contributing towards future nano electronic device applications. MDPI 2023-02-25 /pmc/articles/PMC10004328/ /pubmed/36903408 http://dx.doi.org/10.3390/molecules28052161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Manoharan, Gririraj
Bösel, Petra
Thien, Jannis
Holtmannspötter, Michael
Meingast, Laura
Schmidt, Mercedes
Eickmeier, Henning
Haase, Markus
Maultzsch, Janina
Steinhart, Martin
Wollschläger, Joachim
Palma, Matteo
Meyer, Carola
Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
title Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
title_full Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
title_fullStr Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
title_full_unstemmed Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
title_short Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
title_sort click-functionalization of silanized carbon nanotubes: from inorganic heterostructures to biosensing nanohybrids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004328/
https://www.ncbi.nlm.nih.gov/pubmed/36903408
http://dx.doi.org/10.3390/molecules28052161
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