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Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids
Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide–alkyne cycloaddition reacti...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004328/ https://www.ncbi.nlm.nih.gov/pubmed/36903408 http://dx.doi.org/10.3390/molecules28052161 |
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author | Manoharan, Gririraj Bösel, Petra Thien, Jannis Holtmannspötter, Michael Meingast, Laura Schmidt, Mercedes Eickmeier, Henning Haase, Markus Maultzsch, Janina Steinhart, Martin Wollschläger, Joachim Palma, Matteo Meyer, Carola |
author_facet | Manoharan, Gririraj Bösel, Petra Thien, Jannis Holtmannspötter, Michael Meingast, Laura Schmidt, Mercedes Eickmeier, Henning Haase, Markus Maultzsch, Janina Steinhart, Martin Wollschläger, Joachim Palma, Matteo Meyer, Carola |
author_sort | Manoharan, Gririraj |
collection | PubMed |
description | Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide–alkyne cycloaddition reactions (SPACC). This was characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy and Fourier transform infra-red spectroscopy. Silane–azide-functionalized SWNTs were immobilized from solution onto patterned substrates through dielectrophoresis (DEP). We demonstrate the general applicability of our strategy for the functionalization of SWNTs with metal nanoparticles (gold nanoparticles), fluorescent dyes (Alexa Fluor 647) and biomolecules (aptamers). In this regard, dopamine-binding aptamers were conjugated to the functionalized SWNTs to perform real-time detection of dopamine at different concentrations. Additionally, the chemical route is shown to selectively functionalize individual nanotubes grown on the surface of silicon substrates, contributing towards future nano electronic device applications. |
format | Online Article Text |
id | pubmed-10004328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100043282023-03-11 Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids Manoharan, Gririraj Bösel, Petra Thien, Jannis Holtmannspötter, Michael Meingast, Laura Schmidt, Mercedes Eickmeier, Henning Haase, Markus Maultzsch, Janina Steinhart, Martin Wollschläger, Joachim Palma, Matteo Meyer, Carola Molecules Article Here we present an approach to functionalize silanized single-walled carbon nanotubes (SWNTs) through copper-free click chemistry for the assembly of inorganic and biological nanohybrids. The nanotube functionalization route involves silanization and strain-promoted azide–alkyne cycloaddition reactions (SPACC). This was characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy and Fourier transform infra-red spectroscopy. Silane–azide-functionalized SWNTs were immobilized from solution onto patterned substrates through dielectrophoresis (DEP). We demonstrate the general applicability of our strategy for the functionalization of SWNTs with metal nanoparticles (gold nanoparticles), fluorescent dyes (Alexa Fluor 647) and biomolecules (aptamers). In this regard, dopamine-binding aptamers were conjugated to the functionalized SWNTs to perform real-time detection of dopamine at different concentrations. Additionally, the chemical route is shown to selectively functionalize individual nanotubes grown on the surface of silicon substrates, contributing towards future nano electronic device applications. MDPI 2023-02-25 /pmc/articles/PMC10004328/ /pubmed/36903408 http://dx.doi.org/10.3390/molecules28052161 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Manoharan, Gririraj Bösel, Petra Thien, Jannis Holtmannspötter, Michael Meingast, Laura Schmidt, Mercedes Eickmeier, Henning Haase, Markus Maultzsch, Janina Steinhart, Martin Wollschläger, Joachim Palma, Matteo Meyer, Carola Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids |
title | Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids |
title_full | Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids |
title_fullStr | Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids |
title_full_unstemmed | Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids |
title_short | Click-Functionalization of Silanized Carbon Nanotubes: From Inorganic Heterostructures to Biosensing Nanohybrids |
title_sort | click-functionalization of silanized carbon nanotubes: from inorganic heterostructures to biosensing nanohybrids |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004328/ https://www.ncbi.nlm.nih.gov/pubmed/36903408 http://dx.doi.org/10.3390/molecules28052161 |
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