Cargando…

Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma

Background/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect of glaucoma disease on peripapillary vessel density...

Descripción completa

Detalles Bibliográficos
Autores principales: Gomez, María Sanz, Zeng, Ni, Catagna Catagna, Gloria Estefania, Arribas-Pardo, Paula, Garcia-Feijoo, Julian, Mendez-Hernandez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004387/
https://www.ncbi.nlm.nih.gov/pubmed/36902860
http://dx.doi.org/10.3390/jcm12052071
_version_ 1784904819893338112
author Gomez, María Sanz
Zeng, Ni
Catagna Catagna, Gloria Estefania
Arribas-Pardo, Paula
Garcia-Feijoo, Julian
Mendez-Hernandez, Carmen
author_facet Gomez, María Sanz
Zeng, Ni
Catagna Catagna, Gloria Estefania
Arribas-Pardo, Paula
Garcia-Feijoo, Julian
Mendez-Hernandez, Carmen
author_sort Gomez, María Sanz
collection PubMed
description Background/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect of glaucoma disease on peripapillary vessel density (sPVD) and macular vessel density (sMVD) on the superficial vascular plexus, controlling differences on comorbidities such as SAH, DM and HC between glaucoma patients and normal subjects. Methods: In this prospective, unicenter, observational cross-sectional study, sPVD and sMVD were measured in 155 glaucoma patients and 162 normal subjects. Differences between normal subjects and glaucoma patients’ groups were analyzed. A linear regression model with 95% confidence and 80% statistical power was performed. Results: Parameters with greater effect on sPVD were glaucoma diagnosis, gender, pseudophakia and DM. Glaucoma patients had a sPVD 1.2% lower than healthy subjects (Beta slope 1.228; 95%CI 0.798–1.659, p < 0.0001). Women presented 1.19% more sPVD than men (Beta slope 1.190; 95%CI 0.750–1.631, p < 0.0001), and phakic patients presented 1.7% more sPVD than men (Beta slope 1.795; 95%CI 1.311–2.280, p < 0.0001). Furthermore, DM patients had 0.9% lower sPVD than non-diabetic patients (Beta slope 0.925; 95%CI 0.293–1.558, p = 0.004). SAH and HC did not affect most of the sPVD parameters. Patients with SAH and HC showed 1.5% lower sMVD in the outer circle than subjects without those comorbidities (Beta slope 1.513; 95%CI 0.216–2.858, p = 0.021 and 1.549; 95%CI 0.240–2.858, p = 0.022 respectively. Conclusions: Glaucoma diagnosis, previous cataract surgery, age and gender seem to have greater influence than the presence of SAH, DM and HC on sPVD and sMVD, particularly sPVD.
format Online
Article
Text
id pubmed-10004387
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100043872023-03-11 Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma Gomez, María Sanz Zeng, Ni Catagna Catagna, Gloria Estefania Arribas-Pardo, Paula Garcia-Feijoo, Julian Mendez-Hernandez, Carmen J Clin Med Article Background/Aims: Vascular factors are involved in the development of glaucoma, including diseases such as hypercholesterolemia (HC), systemic arterial hypertension (SAH), and diabetes mellitus (DM). The aim of this study was to determine the effect of glaucoma disease on peripapillary vessel density (sPVD) and macular vessel density (sMVD) on the superficial vascular plexus, controlling differences on comorbidities such as SAH, DM and HC between glaucoma patients and normal subjects. Methods: In this prospective, unicenter, observational cross-sectional study, sPVD and sMVD were measured in 155 glaucoma patients and 162 normal subjects. Differences between normal subjects and glaucoma patients’ groups were analyzed. A linear regression model with 95% confidence and 80% statistical power was performed. Results: Parameters with greater effect on sPVD were glaucoma diagnosis, gender, pseudophakia and DM. Glaucoma patients had a sPVD 1.2% lower than healthy subjects (Beta slope 1.228; 95%CI 0.798–1.659, p < 0.0001). Women presented 1.19% more sPVD than men (Beta slope 1.190; 95%CI 0.750–1.631, p < 0.0001), and phakic patients presented 1.7% more sPVD than men (Beta slope 1.795; 95%CI 1.311–2.280, p < 0.0001). Furthermore, DM patients had 0.9% lower sPVD than non-diabetic patients (Beta slope 0.925; 95%CI 0.293–1.558, p = 0.004). SAH and HC did not affect most of the sPVD parameters. Patients with SAH and HC showed 1.5% lower sMVD in the outer circle than subjects without those comorbidities (Beta slope 1.513; 95%CI 0.216–2.858, p = 0.021 and 1.549; 95%CI 0.240–2.858, p = 0.022 respectively. Conclusions: Glaucoma diagnosis, previous cataract surgery, age and gender seem to have greater influence than the presence of SAH, DM and HC on sPVD and sMVD, particularly sPVD. MDPI 2023-03-06 /pmc/articles/PMC10004387/ /pubmed/36902860 http://dx.doi.org/10.3390/jcm12052071 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gomez, María Sanz
Zeng, Ni
Catagna Catagna, Gloria Estefania
Arribas-Pardo, Paula
Garcia-Feijoo, Julian
Mendez-Hernandez, Carmen
Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
title Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
title_full Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
title_fullStr Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
title_full_unstemmed Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
title_short Effect of Hypercholesterolemia, Systemic Arterial Hypertension and Diabetes Mellitus on Peripapillary and Macular Vessel Density on Superficial Vascular Plexus in Glaucoma
title_sort effect of hypercholesterolemia, systemic arterial hypertension and diabetes mellitus on peripapillary and macular vessel density on superficial vascular plexus in glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004387/
https://www.ncbi.nlm.nih.gov/pubmed/36902860
http://dx.doi.org/10.3390/jcm12052071
work_keys_str_mv AT gomezmariasanz effectofhypercholesterolemiasystemicarterialhypertensionanddiabetesmellitusonperipapillaryandmacularvesseldensityonsuperficialvascularplexusinglaucoma
AT zengni effectofhypercholesterolemiasystemicarterialhypertensionanddiabetesmellitusonperipapillaryandmacularvesseldensityonsuperficialvascularplexusinglaucoma
AT catagnacatagnagloriaestefania effectofhypercholesterolemiasystemicarterialhypertensionanddiabetesmellitusonperipapillaryandmacularvesseldensityonsuperficialvascularplexusinglaucoma
AT arribaspardopaula effectofhypercholesterolemiasystemicarterialhypertensionanddiabetesmellitusonperipapillaryandmacularvesseldensityonsuperficialvascularplexusinglaucoma
AT garciafeijoojulian effectofhypercholesterolemiasystemicarterialhypertensionanddiabetesmellitusonperipapillaryandmacularvesseldensityonsuperficialvascularplexusinglaucoma
AT mendezhernandezcarmen effectofhypercholesterolemiasystemicarterialhypertensionanddiabetesmellitusonperipapillaryandmacularvesseldensityonsuperficialvascularplexusinglaucoma