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LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications

Nowadays, it is vital to have new, complete, and rapid methods to screen and follow pharmacotoxicological and forensic cases. In this context, an important role is undoubtedly played by liquid chromatography-tandem mass spectrometry (LC-MS/MS) thanks to its advanced features. This instrument configu...

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Autores principales: D’Ovidio, Cristian, Locatelli, Marcello, Perrucci, Miryam, Ciriolo, Luigi, Furton, Kenneth G., Gazioglu, Isil, Kabir, Abuzar, Merone, Giuseppe Maria, de Grazia, Ugo, Ali, Imran, Catena, Antonio Maria, Treglia, Michele, Marsella, Luigi T., Savini, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004468/
https://www.ncbi.nlm.nih.gov/pubmed/36903374
http://dx.doi.org/10.3390/molecules28052127
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author D’Ovidio, Cristian
Locatelli, Marcello
Perrucci, Miryam
Ciriolo, Luigi
Furton, Kenneth G.
Gazioglu, Isil
Kabir, Abuzar
Merone, Giuseppe Maria
de Grazia, Ugo
Ali, Imran
Catena, Antonio Maria
Treglia, Michele
Marsella, Luigi T.
Savini, Fabio
author_facet D’Ovidio, Cristian
Locatelli, Marcello
Perrucci, Miryam
Ciriolo, Luigi
Furton, Kenneth G.
Gazioglu, Isil
Kabir, Abuzar
Merone, Giuseppe Maria
de Grazia, Ugo
Ali, Imran
Catena, Antonio Maria
Treglia, Michele
Marsella, Luigi T.
Savini, Fabio
author_sort D’Ovidio, Cristian
collection PubMed
description Nowadays, it is vital to have new, complete, and rapid methods to screen and follow pharmacotoxicological and forensic cases. In this context, an important role is undoubtedly played by liquid chromatography-tandem mass spectrometry (LC-MS/MS) thanks to its advanced features. This instrument configuration can offer comprehensive and complete analysis and is a very potent analytical tool in the hands of analysts for the correct identification and quantification of analytes. The present review paper discusses the applications of LC-MS/MS in pharmacotoxicological cases because it is impossible to ignore the importance of this powerful instrument for the rapid development of pharmacological and forensic advanced research in recent years. On one hand, pharmacology is fundamental for drug monitoring and helping people to find the so-called “personal therapy” or “personalized therapy”. On the other hand, toxicological and forensic LC-MS/MS represents the most critical instrument configuration applied to the screening and research of drugs and illicit drugs, giving critical support to law enforcement. Often the two areas are stackable, and for this reason, many methods include analytes attributable to both fields of application. In this manuscript, drugs and illicit drugs were divided in separate sections, with particular attention paid in the first section to therapeutic drug monitoring (TDM) and clinical approaches with a focus on central nervous system (CNS). The second section is focused on the methods developed in recent years for the determination of illicit drugs, often in combination with CNS drugs. All references considered herein cover the last 3 years, except for some specific and peculiar applications for which some more dated but still recent articles have been considered.
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spelling pubmed-100044682023-03-11 LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications D’Ovidio, Cristian Locatelli, Marcello Perrucci, Miryam Ciriolo, Luigi Furton, Kenneth G. Gazioglu, Isil Kabir, Abuzar Merone, Giuseppe Maria de Grazia, Ugo Ali, Imran Catena, Antonio Maria Treglia, Michele Marsella, Luigi T. Savini, Fabio Molecules Review Nowadays, it is vital to have new, complete, and rapid methods to screen and follow pharmacotoxicological and forensic cases. In this context, an important role is undoubtedly played by liquid chromatography-tandem mass spectrometry (LC-MS/MS) thanks to its advanced features. This instrument configuration can offer comprehensive and complete analysis and is a very potent analytical tool in the hands of analysts for the correct identification and quantification of analytes. The present review paper discusses the applications of LC-MS/MS in pharmacotoxicological cases because it is impossible to ignore the importance of this powerful instrument for the rapid development of pharmacological and forensic advanced research in recent years. On one hand, pharmacology is fundamental for drug monitoring and helping people to find the so-called “personal therapy” or “personalized therapy”. On the other hand, toxicological and forensic LC-MS/MS represents the most critical instrument configuration applied to the screening and research of drugs and illicit drugs, giving critical support to law enforcement. Often the two areas are stackable, and for this reason, many methods include analytes attributable to both fields of application. In this manuscript, drugs and illicit drugs were divided in separate sections, with particular attention paid in the first section to therapeutic drug monitoring (TDM) and clinical approaches with a focus on central nervous system (CNS). The second section is focused on the methods developed in recent years for the determination of illicit drugs, often in combination with CNS drugs. All references considered herein cover the last 3 years, except for some specific and peculiar applications for which some more dated but still recent articles have been considered. MDPI 2023-02-24 /pmc/articles/PMC10004468/ /pubmed/36903374 http://dx.doi.org/10.3390/molecules28052127 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
D’Ovidio, Cristian
Locatelli, Marcello
Perrucci, Miryam
Ciriolo, Luigi
Furton, Kenneth G.
Gazioglu, Isil
Kabir, Abuzar
Merone, Giuseppe Maria
de Grazia, Ugo
Ali, Imran
Catena, Antonio Maria
Treglia, Michele
Marsella, Luigi T.
Savini, Fabio
LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications
title LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications
title_full LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications
title_fullStr LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications
title_full_unstemmed LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications
title_short LC-MS/MS Application in Pharmacotoxicological Field: Current State and New Applications
title_sort lc-ms/ms application in pharmacotoxicological field: current state and new applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004468/
https://www.ncbi.nlm.nih.gov/pubmed/36903374
http://dx.doi.org/10.3390/molecules28052127
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