The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection

Chronic hepatitis B virus (HBV) infection continues to be a global public health burden. B cells play a pivotal role in mediating HBV clearance and can participate in the development of anti-HBV adaptive immune responses through multiple mechanisms, such as antibody production, antigen presentation,...

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Autores principales: Ablikim, Dilhumare, Zeng, Xiaoqing, Xu, Chunli, Zhao, Mengxiao, Yang, Xuecheng, Feng, Xuemei, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004556/
https://www.ncbi.nlm.nih.gov/pubmed/36902786
http://dx.doi.org/10.3390/jcm12052000
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author Ablikim, Dilhumare
Zeng, Xiaoqing
Xu, Chunli
Zhao, Mengxiao
Yang, Xuecheng
Feng, Xuemei
Liu, Jia
author_facet Ablikim, Dilhumare
Zeng, Xiaoqing
Xu, Chunli
Zhao, Mengxiao
Yang, Xuecheng
Feng, Xuemei
Liu, Jia
author_sort Ablikim, Dilhumare
collection PubMed
description Chronic hepatitis B virus (HBV) infection continues to be a global public health burden. B cells play a pivotal role in mediating HBV clearance and can participate in the development of anti-HBV adaptive immune responses through multiple mechanisms, such as antibody production, antigen presentation, and immune regulation. However, B cell phenotypic and functional disorders are frequently observed during chronic HBV infection, suggesting the necessity of targeting the disordered anti-HBV B cell responses to design and test new immune therapeutic strategies for the treatment of chronic HBV infection. In this review, we provide a comprehensive summary of the multiple roles of B cells in mediating HBV clearance and pathogenesis as well as the latest developments in understanding the immune dysfunction of B cells in chronic HBV infection. Additionally, we discuss novel immune therapeutic strategies that aim to enhance anti-HBV B cell responses for curing chronic HBV infection.
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spelling pubmed-100045562023-03-11 The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection Ablikim, Dilhumare Zeng, Xiaoqing Xu, Chunli Zhao, Mengxiao Yang, Xuecheng Feng, Xuemei Liu, Jia J Clin Med Review Chronic hepatitis B virus (HBV) infection continues to be a global public health burden. B cells play a pivotal role in mediating HBV clearance and can participate in the development of anti-HBV adaptive immune responses through multiple mechanisms, such as antibody production, antigen presentation, and immune regulation. However, B cell phenotypic and functional disorders are frequently observed during chronic HBV infection, suggesting the necessity of targeting the disordered anti-HBV B cell responses to design and test new immune therapeutic strategies for the treatment of chronic HBV infection. In this review, we provide a comprehensive summary of the multiple roles of B cells in mediating HBV clearance and pathogenesis as well as the latest developments in understanding the immune dysfunction of B cells in chronic HBV infection. Additionally, we discuss novel immune therapeutic strategies that aim to enhance anti-HBV B cell responses for curing chronic HBV infection. MDPI 2023-03-02 /pmc/articles/PMC10004556/ /pubmed/36902786 http://dx.doi.org/10.3390/jcm12052000 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ablikim, Dilhumare
Zeng, Xiaoqing
Xu, Chunli
Zhao, Mengxiao
Yang, Xuecheng
Feng, Xuemei
Liu, Jia
The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection
title The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection
title_full The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection
title_fullStr The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection
title_full_unstemmed The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection
title_short The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection
title_sort multiple facets and disorders of b cell functions in hepatitis b virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004556/
https://www.ncbi.nlm.nih.gov/pubmed/36902786
http://dx.doi.org/10.3390/jcm12052000
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