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Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest

Cardiogenic Shock (CS) complicated by in-hospital (IHCA) or out-of-hospital cardiac arrest (OHCA) has a poor outcome. However, studies regarding the prognostic differences between IHCA and OHCA in CS are limited. In this prospective, observational study, consecutive patients with CS were included in...

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Autores principales: Rusnak, Jonas, Schupp, Tobias, Weidner, Kathrin, Ruka, Marinela, Egner-Walter, Sascha, Forner, Jan, Bertsch, Thomas, Kittel, Maximilian, Mashayekhi, Kambis, Tajti, Péter, Ayoub, Mohamed, Behnes, Michael, Akin, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004576/
https://www.ncbi.nlm.nih.gov/pubmed/36902851
http://dx.doi.org/10.3390/jcm12052064
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author Rusnak, Jonas
Schupp, Tobias
Weidner, Kathrin
Ruka, Marinela
Egner-Walter, Sascha
Forner, Jan
Bertsch, Thomas
Kittel, Maximilian
Mashayekhi, Kambis
Tajti, Péter
Ayoub, Mohamed
Behnes, Michael
Akin, Ibrahim
author_facet Rusnak, Jonas
Schupp, Tobias
Weidner, Kathrin
Ruka, Marinela
Egner-Walter, Sascha
Forner, Jan
Bertsch, Thomas
Kittel, Maximilian
Mashayekhi, Kambis
Tajti, Péter
Ayoub, Mohamed
Behnes, Michael
Akin, Ibrahim
author_sort Rusnak, Jonas
collection PubMed
description Cardiogenic Shock (CS) complicated by in-hospital (IHCA) or out-of-hospital cardiac arrest (OHCA) has a poor outcome. However, studies regarding the prognostic differences between IHCA and OHCA in CS are limited. In this prospective, observational study, consecutive patients with CS were included in a monocentric registry from June 2019 to May 2021. The prognostic impact of IHCA and OHCA on 30-day all-cause mortality was tested within the entire group and in the subgroups of patients with acute myocardial infarction (AMI) and coronary artery disease (CAD). Statistical analyses included univariable t-test, Spearman’s correlation, Kaplan–Meier analyses, as well as uni- and multivariable Cox regression analyses. A total of 151 patients with CS and cardiac arrest were included. IHCA on ICU admission was associated with higher 30-day all-cause mortality compared to OHCA in univariable COX regression and Kaplan–Meier analyses. However, this association was solely driven by patients with AMI (77% vs. 63%; log rank p = 0.023), whereas IHCA was not associated with 30-day all-cause mortality in non-AMI patients (65% vs. 66%; log rank p = 0.780). This finding was confirmed in multivariable COX regression, in which IHCA was solely associated with higher 30-day all-cause mortality in patients with AMI (HR = 2.477; 95% CI 1.258–4.879; p = 0.009), whereas no significant association could be seen in the non-AMI group and in the subgroups of patients with and CAD. CS patients with IHCA showed significantly higher all-cause mortality at 30 days compared to patients with OHCA. This finding was primarily driven by a significant increase in all-cause mortality at 30 days in CS patients with AMI and IHCA, whereas no difference could be seen when differentiated by CAD.
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spelling pubmed-100045762023-03-11 Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest Rusnak, Jonas Schupp, Tobias Weidner, Kathrin Ruka, Marinela Egner-Walter, Sascha Forner, Jan Bertsch, Thomas Kittel, Maximilian Mashayekhi, Kambis Tajti, Péter Ayoub, Mohamed Behnes, Michael Akin, Ibrahim J Clin Med Article Cardiogenic Shock (CS) complicated by in-hospital (IHCA) or out-of-hospital cardiac arrest (OHCA) has a poor outcome. However, studies regarding the prognostic differences between IHCA and OHCA in CS are limited. In this prospective, observational study, consecutive patients with CS were included in a monocentric registry from June 2019 to May 2021. The prognostic impact of IHCA and OHCA on 30-day all-cause mortality was tested within the entire group and in the subgroups of patients with acute myocardial infarction (AMI) and coronary artery disease (CAD). Statistical analyses included univariable t-test, Spearman’s correlation, Kaplan–Meier analyses, as well as uni- and multivariable Cox regression analyses. A total of 151 patients with CS and cardiac arrest were included. IHCA on ICU admission was associated with higher 30-day all-cause mortality compared to OHCA in univariable COX regression and Kaplan–Meier analyses. However, this association was solely driven by patients with AMI (77% vs. 63%; log rank p = 0.023), whereas IHCA was not associated with 30-day all-cause mortality in non-AMI patients (65% vs. 66%; log rank p = 0.780). This finding was confirmed in multivariable COX regression, in which IHCA was solely associated with higher 30-day all-cause mortality in patients with AMI (HR = 2.477; 95% CI 1.258–4.879; p = 0.009), whereas no significant association could be seen in the non-AMI group and in the subgroups of patients with and CAD. CS patients with IHCA showed significantly higher all-cause mortality at 30 days compared to patients with OHCA. This finding was primarily driven by a significant increase in all-cause mortality at 30 days in CS patients with AMI and IHCA, whereas no difference could be seen when differentiated by CAD. MDPI 2023-03-06 /pmc/articles/PMC10004576/ /pubmed/36902851 http://dx.doi.org/10.3390/jcm12052064 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rusnak, Jonas
Schupp, Tobias
Weidner, Kathrin
Ruka, Marinela
Egner-Walter, Sascha
Forner, Jan
Bertsch, Thomas
Kittel, Maximilian
Mashayekhi, Kambis
Tajti, Péter
Ayoub, Mohamed
Behnes, Michael
Akin, Ibrahim
Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest
title Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest
title_full Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest
title_fullStr Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest
title_full_unstemmed Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest
title_short Differences in Outcome of Patients with Cardiogenic Shock Associated with In-Hospital or Out-of-Hospital Cardiac Arrest
title_sort differences in outcome of patients with cardiogenic shock associated with in-hospital or out-of-hospital cardiac arrest
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004576/
https://www.ncbi.nlm.nih.gov/pubmed/36902851
http://dx.doi.org/10.3390/jcm12052064
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