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LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors in human tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of...

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Autores principales: Hao, Longhui, Wu, Wenzheng, Xu, Yankun, Chen, Yufan, Meng, Chengzhen, Yun, Jingyi, Wang, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004581/
https://www.ncbi.nlm.nih.gov/pubmed/36903369
http://dx.doi.org/10.3390/molecules28052126
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author Hao, Longhui
Wu, Wenzheng
Xu, Yankun
Chen, Yufan
Meng, Chengzhen
Yun, Jingyi
Wang, Xiaoyu
author_facet Hao, Longhui
Wu, Wenzheng
Xu, Yankun
Chen, Yufan
Meng, Chengzhen
Yun, Jingyi
Wang, Xiaoyu
author_sort Hao, Longhui
collection PubMed
description LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors in human tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of human tissue, activation, and the regulation of proto-oncogenes, the differentiation of immune cells, and the regulation of the cellular immune system. The lncRNA metastasis-associated lung cancer transcript 1 (MALAT1) is reportedly involved in the occurrence and development of many cancers and serves as a biomarker and therapeutic target. These findings highlight its promising role in cancer treatment. In this article, we comprehensively summarized the structure and functions of lncRNA, notably the discoveries of lncRNA-MALAT1 in different cancers, the action mechanisms, and the ongoing research on new drug development. We believe our review would serve as a basis for further research on the pathological mechanism of lncRNA-MALAT1 in cancer and provide evidence and novel insights into its application in clinical diagnoses and treatments.
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spelling pubmed-100045812023-03-11 LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer Hao, Longhui Wu, Wenzheng Xu, Yankun Chen, Yufan Meng, Chengzhen Yun, Jingyi Wang, Xiaoyu Molecules Review LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors in human tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of human tissue, activation, and the regulation of proto-oncogenes, the differentiation of immune cells, and the regulation of the cellular immune system. The lncRNA metastasis-associated lung cancer transcript 1 (MALAT1) is reportedly involved in the occurrence and development of many cancers and serves as a biomarker and therapeutic target. These findings highlight its promising role in cancer treatment. In this article, we comprehensively summarized the structure and functions of lncRNA, notably the discoveries of lncRNA-MALAT1 in different cancers, the action mechanisms, and the ongoing research on new drug development. We believe our review would serve as a basis for further research on the pathological mechanism of lncRNA-MALAT1 in cancer and provide evidence and novel insights into its application in clinical diagnoses and treatments. MDPI 2023-02-24 /pmc/articles/PMC10004581/ /pubmed/36903369 http://dx.doi.org/10.3390/molecules28052126 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hao, Longhui
Wu, Wenzheng
Xu, Yankun
Chen, Yufan
Meng, Chengzhen
Yun, Jingyi
Wang, Xiaoyu
LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
title LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
title_full LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
title_fullStr LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
title_full_unstemmed LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
title_short LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer
title_sort lncrna-malat1: a key participant in the occurrence and development of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004581/
https://www.ncbi.nlm.nih.gov/pubmed/36903369
http://dx.doi.org/10.3390/molecules28052126
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