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Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton’s tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics

Tirabrutinib is a highly selective Bruton’s tyrosine kinase (BTK) inhibitor used to treat hematological malignancies. We analyzed the anti-tumor mechanism of tirabrutinib using phosphoproteomic and transcriptomic methods. It is important to check the drug’s selectivity against off-target proteins to...

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Detalles Bibliográficos
Autores principales:	Kozaki, Ryohei, Yasuhiro, Tomoko, Kato, Hikaru, Murai, Jun, Hotta, Shingo, Ariza, Yuko, Sakai, Shunsuke, Fujikawa, Ryu, Yoshida, Takao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10004634/ https://www.ncbi.nlm.nih.gov/pubmed/36897912 http://dx.doi.org/10.1371/journal.pone.0282166

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