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Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action

Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in traditional medicine. The diverse biological properties of carnosic acid that include antioxidant, anti-inflammatory, and anticarcinog...

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Autores principales: Mirza, Fatima Javed, Zahid, Saadia, Holsinger, R. M. Damian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005014/
https://www.ncbi.nlm.nih.gov/pubmed/36903551
http://dx.doi.org/10.3390/molecules28052306
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author Mirza, Fatima Javed
Zahid, Saadia
Holsinger, R. M. Damian
author_facet Mirza, Fatima Javed
Zahid, Saadia
Holsinger, R. M. Damian
author_sort Mirza, Fatima Javed
collection PubMed
description Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in traditional medicine. The diverse biological properties of carnosic acid that include antioxidant, anti-inflammatory, and anticarcinogenic activities have instigated studies on its mechanistic role, providing further insights into its potential as a therapeutic agent. Accumulating evidence has established the relevance of carnosic acid as a neuroprotective agent exhibiting therapeutic efficacy in combatting neuronal-injury-induced disorders. The physiological importance of carnosic acid in the mitigation of neurodegenerative disorders is just beginning to be understood. This review summarizes the current data on the mode of action through which carnosic acid exerts its neuroprotective role that may serve to strategize novel therapeutic approaches for these debilitating neurodegenerative disorders.
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spelling pubmed-100050142023-03-11 Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action Mirza, Fatima Javed Zahid, Saadia Holsinger, R. M. Damian Molecules Review Carnosic acid is a diterpenoid abundantly present in plants belonging to the genus Rosmarinus and Salvia of the family Lamiaceae, accounting for their application in traditional medicine. The diverse biological properties of carnosic acid that include antioxidant, anti-inflammatory, and anticarcinogenic activities have instigated studies on its mechanistic role, providing further insights into its potential as a therapeutic agent. Accumulating evidence has established the relevance of carnosic acid as a neuroprotective agent exhibiting therapeutic efficacy in combatting neuronal-injury-induced disorders. The physiological importance of carnosic acid in the mitigation of neurodegenerative disorders is just beginning to be understood. This review summarizes the current data on the mode of action through which carnosic acid exerts its neuroprotective role that may serve to strategize novel therapeutic approaches for these debilitating neurodegenerative disorders. MDPI 2023-03-02 /pmc/articles/PMC10005014/ /pubmed/36903551 http://dx.doi.org/10.3390/molecules28052306 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mirza, Fatima Javed
Zahid, Saadia
Holsinger, R. M. Damian
Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
title Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
title_full Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
title_fullStr Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
title_full_unstemmed Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
title_short Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
title_sort neuroprotective effects of carnosic acid: insight into its mechanisms of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005014/
https://www.ncbi.nlm.nih.gov/pubmed/36903551
http://dx.doi.org/10.3390/molecules28052306
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