An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful for the development of a new class of anticancer drugs....

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Autores principales: Aksenov, Dmitrii A., Akulova, Alesia S., Aleksandrova, Elena A., Aksenov, Nicolai A., Leontiev, Alexander V., Aksenov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005103/
https://www.ncbi.nlm.nih.gov/pubmed/36903571
http://dx.doi.org/10.3390/molecules28052324
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author Aksenov, Dmitrii A.
Akulova, Alesia S.
Aleksandrova, Elena A.
Aksenov, Nicolai A.
Leontiev, Alexander V.
Aksenov, Alexander V.
author_facet Aksenov, Dmitrii A.
Akulova, Alesia S.
Aleksandrova, Elena A.
Aksenov, Nicolai A.
Leontiev, Alexander V.
Aksenov, Alexander V.
author_sort Aksenov, Dmitrii A.
collection PubMed
description A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful for the development of a new class of anticancer drugs.
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spelling pubmed-100051032023-03-11 An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones Aksenov, Dmitrii A. Akulova, Alesia S. Aleksandrova, Elena A. Aksenov, Nicolai A. Leontiev, Alexander V. Aksenov, Alexander V. Molecules Article A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful for the development of a new class of anticancer drugs. MDPI 2023-03-02 /pmc/articles/PMC10005103/ /pubmed/36903571 http://dx.doi.org/10.3390/molecules28052324 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aksenov, Dmitrii A.
Akulova, Alesia S.
Aleksandrova, Elena A.
Aksenov, Nicolai A.
Leontiev, Alexander V.
Aksenov, Alexander V.
An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
title An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
title_full An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
title_fullStr An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
title_full_unstemmed An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
title_short An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
title_sort effective synthesis of previously unknown 7-aryl substituted paullones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005103/
https://www.ncbi.nlm.nih.gov/pubmed/36903571
http://dx.doi.org/10.3390/molecules28052324
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