Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS ana...

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Detalles Bibliográficos
Autores principales: Shi, Jianwei, Wang, Zhichuan, Teng, Xiaoxu, Zhang, Bing, Sun, Kai, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005275/
https://www.ncbi.nlm.nih.gov/pubmed/36903450
http://dx.doi.org/10.3390/molecules28052206
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author Shi, Jianwei
Wang, Zhichuan
Teng, Xiaoxu
Zhang, Bing
Sun, Kai
Wang, Xin
author_facet Shi, Jianwei
Wang, Zhichuan
Teng, Xiaoxu
Zhang, Bing
Sun, Kai
Wang, Xin
author_sort Shi, Jianwei
collection PubMed
description In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.
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spelling pubmed-100052752023-03-11 Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones Shi, Jianwei Wang, Zhichuan Teng, Xiaoxu Zhang, Bing Sun, Kai Wang, Xin Molecules Article In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed. MDPI 2023-02-27 /pmc/articles/PMC10005275/ /pubmed/36903450 http://dx.doi.org/10.3390/molecules28052206 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Jianwei
Wang, Zhichuan
Teng, Xiaoxu
Zhang, Bing
Sun, Kai
Wang, Xin
Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
title Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
title_full Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
title_fullStr Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
title_full_unstemmed Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
title_short Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
title_sort electro-oxidative c3-selenylation of pyrido[1,2-a]pyrimidin-4-ones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10005275/
https://www.ncbi.nlm.nih.gov/pubmed/36903450
http://dx.doi.org/10.3390/molecules28052206
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AT zhangbing electrooxidativec3selenylationofpyrido12apyrimidin4ones
AT sunkai electrooxidativec3selenylationofpyrido12apyrimidin4ones
AT wangxin electrooxidativec3selenylationofpyrido12apyrimidin4ones

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